3.5.4.5 (cytidyl)acryloylaminohexanoic acid i.e. CV6 35854 3.5.4.5 1,10-phenanthroline - 62 3.5.4.5 1-(beta-D-ribofuranosyl)-2-pyrimidone - 21436 3.5.4.5 1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one zebularine 21437 3.5.4.5 1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one - 21437 3.5.4.5 1-methyladenosine competitive inhibition 10464 3.5.4.5 2'-deoxyuridine - 1705 3.5.4.5 2'-deoxyzebularine 5'-monophosphate - 104402 3.5.4.5 2-beta-D-ribofuranosyl-1,2,4-triazol-3-one - 104515 3.5.4.5 2-mercaptoethanol - 63 3.5.4.5 2-thio-6-azarudine - 104656 3.5.4.5 3'-azido-3'-deoxythymidine - 1185 3.5.4.5 3,4,5,6,tetrahydrozebularine - 48569 3.5.4.5 3,4,5,6-Tetrahydrouridine potent competitive inhibitor 2933 3.5.4.5 3,4,5,6-Tetrahydrouridine - 2933 3.5.4.5 3,4,5,6-Tetrahydrouridine recombinant CDA 2933 3.5.4.5 3,4,5,6-Tetrahydrouridine i.e. THU 2933 3.5.4.5 3,4-dihydrouridine - 48571 3.5.4.5 3,4-dihydrozebularine - 48575 3.5.4.5 3-deazauridine - 12336 3.5.4.5 3-deazauridine recombinant enzyme 12336 3.5.4.5 4-amino-1-(5-hydroxypentyl)pyrimidin-2(1H)-one - 105756 3.5.4.5 4-amino-1-hexyl-5,6-dihydropyrimidin-2(1H)-one - 105755 3.5.4.5 4-hydroxy-1-(beta-D-ribofuranosyl)piperidin-2-one - 105754 3.5.4.5 5,6-Dihydrouridine competitive inhibition 4769 3.5.4.5 5,6-Dihydrouridine - 4769 3.5.4.5 5-(Chloromercuri)cytidine - 20034 3.5.4.5 5-bromodeoxyuridine - 3317 3.5.4.5 5-bromodeoxyuridine 1.0 mM, 31% inhibition 3317 3.5.4.5 5-Bromouridine - 4215 3.5.4.5 5-fluoro-2'-deoxyuridine - 3318 3.5.4.5 5-fluoro-2'-deoxyuridine recombinant enzyme 3318 3.5.4.5 5-fluoropyrimidin-2-one ribonucleoside - 105119 3.5.4.5 5-fluorouridine - 2938 3.5.4.5 5-fluorozebularine - 5302 3.5.4.5 5-iodo-2'-deoxyuridine - 6124 3.5.4.5 5-methyluridine - 3184 3.5.4.5 5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine - 32183 3.5.4.5 5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine recombinant enzyme 32183 3.5.4.5 6-azauridine - 2133 3.5.4.5 6-thioguanine - 1253 3.5.4.5 6-[3-(5-cytidyl)acryloylamino]hexanoic acid i.e. CV6 37848 3.5.4.5 acetone - 333 3.5.4.5 adenosine 4.0 mM, 22% inhibition 122 3.5.4.5 adenosine - 122 3.5.4.5 Ag+ - 75 3.5.4.5 ara-U - 105467 3.5.4.5 blasticidin S - 3195 3.5.4.5 Borate - 1395 3.5.4.5 CDP - 212 3.5.4.5 CMP 0.300 mM 50% inhibition, 0.750 mM 90% inhibition 100 3.5.4.5 CMP - 100 3.5.4.5 CMP recombinant CDA 100 3.5.4.5 CTP - 60 3.5.4.5 Cu2+ - 19 3.5.4.5 CuSO4 complete inhibition 263 3.5.4.5 cytidine strong substrate inhibition above 0.5 mM 372 3.5.4.5 cytidine monophosphate - 24116 3.5.4.5 dCMP - 450 3.5.4.5 deoxyadenosine 3.0 mM, 32% inhibition 601 3.5.4.5 deoxyadenosine competitive inhibition 601 3.5.4.5 deoxyadenosine - 601 3.5.4.5 deoxyguanosine 1.0 mM, 13% inhibition 732 3.5.4.5 deoxyguanosine - 732 3.5.4.5 deoxyuridine - 1060 3.5.4.5 deoxyuridine 1.0 mM, 32% inhibition 1060 3.5.4.5 deoxyuridine competitive inhibition 1060 3.5.4.5 diazepinone riboside - 32200 3.5.4.5 diazepinone riboside inhibitor is able to establish a canonical pi/pi interaction with key active site residue F137 32200 3.5.4.5 dihydrothymidine competitive inhibition 32203 3.5.4.5 dipicolinic acid - 1443 3.5.4.5 dithiothreitol - 45 3.5.4.5 dTMP 0.400 mM 50% inhibition 635 3.5.4.5 DTNB - 554 3.5.4.5 dTTP - 145 3.5.4.5 dTTP 0.400 mM 50% inhibition 145 3.5.4.5 dUTP - 435 3.5.4.5 EDTA - 21 3.5.4.5 Fe2+ - 25 3.5.4.5 Fe3+ - 70 3.5.4.5 GTP 0.750 mM 85% inhibition 37 3.5.4.5 guanosine 1.0 mM, 4% inhibition 296 3.5.4.5 guanosine - 296 3.5.4.5 Hg+ - 1756 3.5.4.5 HgCl2 complete inhibition 110 3.5.4.5 mercaptoethanol - 1623 3.5.4.5 Mersalyl acid - 3084 3.5.4.5 N-ethylmaleimide - 49 3.5.4.5 N-ethylmaleimide weak inhibition 49 3.5.4.5 NH3 product inhibition 27 3.5.4.5 NH3 - 27 3.5.4.5 p-chloromercuribenzoate - 43 3.5.4.5 p-mercuribenzoate highly sensitive 686 3.5.4.5 p-mercuribenzoate - 686 3.5.4.5 p-mercuribenzoate enzyme from leukemic spleen, enzyme from normal spleen is much less sensitive 686 3.5.4.5 phosphapyrimidine - 107056 3.5.4.5 phosphapyrimidine nucleoside - 107057 3.5.4.5 pseudouridine - 7276 3.5.4.5 SDS wild-type tetramer dissociates into enzymatically inactive monomers, without intermediate forms via a non-cooperative transition. Extensive dialysis or dilution of the inativated monomers restores completely the activity. 5-Fluorozebularine disfavours dissociation of the tetramer into subunits in the wild-type enzyme, but not in the mutant enzyme F137W/W113F 124 3.5.4.5 tetrahydrouridine - 13414 3.5.4.5 tetrahydrouridine i.e. THU, acts as as a transition-state analogue of the natural substrate cytidine, quantitative determination of the cytidine deaminase inhibitor in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry, pharmacokinetics, overview 13414 3.5.4.5 tetrahydrouridine THU, the presence of 1 microM totally prevents the formation of 5'-deoxy-5-fluorouridine in blood samples of healthy volunteers and capecitabine-treated patients 13414 3.5.4.5 thioglycolic acid 0.7 mM 88% relative activity, complete inhibition at 7 mM 2360 3.5.4.5 thymidine 1.0 mM, 21% inhibition 166 3.5.4.5 thymidine competitive inhibition 166 3.5.4.5 thymidine - 166 3.5.4.5 thymine riboside competitive inhibition 11161 3.5.4.5 thymine riboside - 11161 3.5.4.5 thymine riboside recombinant CDA 11161 3.5.4.5 uracil arabinoside 4.0 mM, 48% inhibition 20565 3.5.4.5 Urea above 2 M, reversible inactivation 116 3.5.4.5 uridine - 261 3.5.4.5 uridine product inhibition 261 3.5.4.5 uridine 4.0 mM, 20% inhibition 261 3.5.4.5 uridine inhibition relatively slow 261 3.5.4.5 uridine recombinant enzyme 261 3.5.4.5 UTP - 65 3.5.4.5 UTP recombinant CDA 65 3.5.4.5 zebularine inhibits the enzyme, but also DNA methylation, competitive versus 5-aza-2'-deoxycytidine, zebularine affects the antineoplastic action of 5-AZA-CdR on 3T3 cells and V5 cells transduced with CR deaminase gene, overview 6183 3.5.4.5 Zn2+ above 10 mM 14