3.2.2.29 2'-fluoro-2'-deoxyuridine - 104403 3.2.2.29 2'-fluoroarabino-5-formylcytidine - 232853 3.2.2.29 Ca2+ slight inhibition of the enzymic activity 15 3.2.2.29 Co2+ complete inhibition at 5 mM 23 3.2.2.29 Cu2+ complete inhibition at 5 mM 19 3.2.2.29 Mg2+ slight inhibition of the enzymic activity 6 3.2.2.29 Mn2+ complete inhibition at 5 mM 11 3.2.2.29 additional information no inhibition of TDG activity on methylated G:IU mispairs by the methyl binding domain 2 3.2.2.29 additional information additional mismatch located at 3' of T/G have less inhibitory effect on the thymine removal than that located at 5' of T/G. Two additional mismatches located at each side of T/G completely inhibit the excision of thymine 2 3.2.2.29 additional information sumoylation dramatically impairs the enzyme's base-excision activity, such that guanine-thymine activity is reduced by more than 45fold and 5-formylcytosine and 5-carboxylcytosine are excised slowly, with a reaction half-life of more than 9 min at 37°C 2 3.2.2.29 NaCl NaCl completely inhibits the thymine removal at 0.4 M 42 3.2.2.29 Ni2+ complete inhibition at 5 mM 38 3.2.2.29 Zn2+ complete inhibition at 5 mM 14