3.2.1.106 1-deoxymannojirimycin very slight inhibition, Ki = 0.19 mM 1183 3.2.1.106 1-deoxynojirimycin strong inhibition 557 3.2.1.106 1-deoxynojirimycin 50% inhibition 557 3.2.1.106 1-deoxynojirimycin - 557 3.2.1.106 1-deoxynojirimycin 0.01 mM: 50% inhibition 557 3.2.1.106 1-deoxynojirimycin 0.01 mM: 80% inhibition; strong inhibition 557 3.2.1.106 1-deoxynojirimycin strong inhibition; strong inhibition, Ki = 0.0021 mM 557 3.2.1.106 1-deoxynojirimycin strong inhibition; strong inhibition, Ki = 0.0001 mM 557 3.2.1.106 2,5-Dihydroxymethyl-3,4-dihydroxypyrrolidine plant pyrrolidine alkaloid, DMDP, 0.04 mM: 50% inhibition 43045 3.2.1.106 2,6-anhydro-1-benzamide-D-glycero-D-ido-heptitol 18.2% inhibition at 1 mM 55955 3.2.1.106 4-nitrophenyl-2-deoxy-alpha-D-glucopyranoside 56.2% inhibition at 5 mM 123075 3.2.1.106 4-nitrophenyl-3-deoxy-alpha-D-glucopyranoside 71.7% inhibition at 5 mM 123076 3.2.1.106 4-nitrophenyl-4-deoxy-alpha-D-glucopyranoside 18.5% inhibition at 5 mM 123077 3.2.1.106 4-nitrophenyl-5-deoxy-alpha-D-glucopyranoside 22.2% inhibition at 5 mM 123078 3.2.1.106 4-nitrophenyl-6-deoxy-alpha-D-glucopyranoside 32.3% inhibition at 5 mM 123079 3.2.1.106 Ag+ potent inhibitor, inhibition reversed by adding an excess of dithiothreitol 75 3.2.1.106 australine 39% inhibition at 0.02 mM 23098 3.2.1.106 bromoconduritol 22% inhibition at 0.02 mM 11039 3.2.1.106 castanospermine 15% inhibition 740 3.2.1.106 castanospermine - 740 3.2.1.106 castanospermine plant indolizidine alkaloid, strong inhibition 740 3.2.1.106 chloride inhibitory above 0.3 M, 0.5 M: 30% inhibition 298 3.2.1.106 CM-9-78 - 39885 3.2.1.106 Co2+ quite inhibitory 23 3.2.1.106 Co2+ potent inhibitor, inhibition reversed by adding an excess of dithiothreitol 23 3.2.1.106 Cu2+ quite inhibitory 19 3.2.1.106 Cu2+ potent inhibitor, inhibition reversed by adding an excess of dithiothreitol 19 3.2.1.106 Cu2+ - 19 3.2.1.106 Cu2+ partial inhibition 19 3.2.1.106 D-glucose 5 mM: 25% inhibition 35 3.2.1.106 D-glucose no significant inhibition, 10 mM: 13% inhibition 35 3.2.1.106 D-glucose - 35 3.2.1.106 D-mannose 1 mM: 4% inhibition, 25 mM: 60% inhibition 216 3.2.1.106 D-mannose 5 mM: 25% inhibition 216 3.2.1.106 D-mannose 10 mM: no inhibition 216 3.2.1.106 deoxynojirimycin - 1922 3.2.1.106 diethyl dicarbonate 55% inhibition at 1 mM after 30 min 463 3.2.1.106 ethanolamine - 456 3.2.1.106 ethyl-3-(3-(dimethylamino)propyl)carbodiimide 90% inhibition at 50 mM after 60 min at pH 6.8, 4°C, preincubation with deoxynorjirmycin prevents 123074 3.2.1.106 glycerol 2% or higher: 25% or more inhibition 135 3.2.1.106 heavy-metal ions potent inhibitors, inhibition reversed by adding an excess of dithiothreitol 102866 3.2.1.106 Hg2+ potent inhibitor, inhibition reversed by adding an excess of dithiothreitol 33 3.2.1.106 kojibiose alpha-1,2-linked glucose disaccharide 1470 3.2.1.106 kojibiose - 1470 3.2.1.106 kojibiose 0.5 mM: 50% inhibition; alpha-1,2-linked glucose disaccharide 1470 3.2.1.106 kojibiose 1 mM: 76% inhibition; alpha-1,2-linked glucose disaccharide 1470 3.2.1.106 kojibiose alpha-1,2-linked glucose disaccharide; Ki = 0.095 mM 1470 3.2.1.106 Man9GlcNAc 1 mM thyroglobulin-derived Man9GlcNAc: 22% inhibition 5643 3.2.1.106 mannose - 988 3.2.1.106 Mg2+ slight inhibition 6 3.2.1.106 Mn2+ slight inhibition 11 3.2.1.106 additional information - 2 3.2.1.106 additional information no inhibition by 1 mM EDTA or 1 mM o-phenanthroline 2 3.2.1.106 additional information no inhibition by dithiothreitol, 2-mercaptoethanol, Mg2+, Mn2+, EDTA, potassium phosphate 2 3.2.1.106 additional information no inhibition by EDTA 2 3.2.1.106 additional information no inhibition by bromoconduritol 2 3.2.1.106 additional information inhibitors of processing glucosidase enhances anti CD3-induced interleukin-2 production and cause an accumulation of glucose-containing high-mannose-type oligosaccharides and suppress the secretion of interleukin-4, interferon-gamma and interleukin-5. Processing inhibitors inhibit the N-linked oligosaccharide processing of cytokines, inhibition of processing enzyme glucosidase I induces a decreased secretion of cytokines with N-linked oligosaccharides 2 3.2.1.106 additional information no inhibition by alpha- or beta-linked glucose disaccharides; no inhibition by methyl-beta-D-glucoside, sophorose laminaribiose, cellobiose, gentiobiose and methyl-alpha-D-glucoside 2 3.2.1.106 additional information no inhibition by alpha-1,3-, alpha-1,4-, and alpha-1,6-linked glucose disaccharides; no inhibition by EDTA; no inhibition by nigerose, maltose, isomaltose at 2 mM; no inhibition by swainsonine, deoxymannojirimycin or 1,4-dideoxy-1,4-imino-D-mannitol 2 3.2.1.106 additional information no inhibition by conduritol B epoxide, bromoconduritols a and B, acarbose at 1 mM 2 3.2.1.106 additional information no inhibition by 1-deoxymannojirimycin 2 3.2.1.106 additional information no inhibition by alpha,alpha'-bipyridyl and o-phenanthroline; no inhibition by EDTA; no significant inhibition by nigerose, Glc(alpha1-3)Glc disaccharide, maltose, gentibiose, cellobiose, sucrose 2 3.2.1.106 additional information inhibition of glucosidase I as a function of pH, pH dependence of inhibition, the inhibiting species is the cationic form of the inhibitor; no inhibition by EDTA 2 3.2.1.106 additional information 2-deoxyglucose, 3-deoxyglucose or 6-deoxyglucose do not have any effect on the enzyme activity; the enzyme is completely insensitive to diethyl pyrocarbonate 2 3.2.1.106 N,N-dimethyl-1-deoxynojirimycin strong inhibition 6110 3.2.1.106 N,N-dimethyl-1-deoxynojirimycin specific inhibitor; strong inhibition 6110 3.2.1.106 N,N-dimethyl-1-deoxynojirimycin strong inhibition; strong inhibition, Ki = 0.0005 mM 6110 3.2.1.106 N,N-dimethyl-1-deoxynojirimycin strong inhibition; strong inhibition, Ki = 0.0004 mM 6110 3.2.1.106 N-(5-carboxypentyl)-1-deoxynojirimycin strong inhibition 7404 3.2.1.106 N-(5-carboxypentyl)-1-deoxynojirimycin slight inhibition 7404 3.2.1.106 N-(5-carboxypentyl)-1-deoxynojirimycin - 7404 3.2.1.106 N-(5-carboxypentyl)-1-deoxynojirimycin strong inhibition; strong specific inhibition, Ki = 0.00045 mM 7404 3.2.1.106 N-(5-carboxypentyl)-1-deoxynojirimycin strong inhibition; strong inhibition, Ki = 0.0005 mM 7404 3.2.1.106 N-(6'-(2'',4''-dinitrophenylamino)hexyl)-1-deoxynojirimycin - 77976 3.2.1.106 N-(6'-(4''-azido-2''-nitrophenylamino)hexyl)-1-deoxynojirimycin highly potent inhibitor of alpha-glucosidase I 77975 3.2.1.106 N-5-carboxypentyl-1-deoxymannojirimycin very slight inhibition, Ki = 0.1 mM 47992 3.2.1.106 N-butyl-1-deoxynojirimycin strong inhibition, Ki = 0.00009 mM 11067 3.2.1.106 N-butyl-deoxynojirimycin - 7722 3.2.1.106 N-butyldeoxynojirimycin - 3896 3.2.1.106 N-decanoyl-1-deoxynojirimycin very slight inhibition, Ki = 0.07 mM 48020 3.2.1.106 N-decyl-1-deoxynojirimycin strong inhibition, Ki = 0.0004 mM 16521 3.2.1.106 N-dodecyl-1-deoxynojirimycin slight inhibition 11068 3.2.1.106 N-ethylmaleimide inhibition when membranes are disrupted with Lubrol PX or saponin, inhibition abolished completely in the presence of dithiothreitol 49 3.2.1.106 N-ethylmaleimide - 49 3.2.1.106 N-hexyl-1-deoxynojirimycin strong inhibition, Ki = 0.00013 mM 31863 3.2.1.106 N-methyl-1-deoxymannojirimycin very slight inhibition, Ki = 0.017 mM 48028 3.2.1.106 N-methyl-1-deoxynojirimycin strong inhibition 8152 3.2.1.106 N-methyl-1-deoxynojirimycin - 8152 3.2.1.106 N-methyl-1-deoxynojirimycin strong inhibition; strong inhibition, Ki = 0.00007 mM 8152 3.2.1.106 N-nonyl-deoxynojirimycin - 10257 3.2.1.106 nigerose - 1561 3.2.1.106 Nojirimycin potent inhibitor 5586 3.2.1.106 Nojirimycin strong inhibition, 0.1 mM: 40% inhibition, 0.16 mM: 50% inhibition 5586 3.2.1.106 octyl-beta-glucoside 10 mM: 90% inhibition 30299 3.2.1.106 octyl-beta-glucoside - 30299 3.2.1.106 OSL-95II - 39884 3.2.1.106 p-Aminophenyl-beta-thioglucoside 100 mM: 73% inhibition 94582 3.2.1.106 p-nitrophenyl-alpha-D-glucoside 5 mM 2212 3.2.1.106 p-nitrophenyl-alpha-D-glucoside 0.0005 mM: 19% inhibition 2212 3.2.1.106 p-nitrophenyl-alpha-D-glucoside - 2212 3.2.1.106 p-nitrophenyl-beta-D-glucoside 5 mM 2213 3.2.1.106 p-nitrophenyl-beta-D-glucoside 0.0005 mM: 14% inhibition 2213 3.2.1.106 p-nitrophenyl-beta-D-glucoside - 2213 3.2.1.106 PBDNJ0801 - 39886 3.2.1.106 PBDNJ0803 - 39887 3.2.1.106 PBDNJ0804 - 39888 3.2.1.106 phosphate inhibitory above 0.3 M, 0.5 M: 30% inhibition 16 3.2.1.106 SDS strong inhibition 124 3.2.1.106 sulfate 0.1-0.2 M: 15-20% inhibition, somewhate more inhibitory at higher concentrations 160 3.2.1.106 tricine - 30481 3.2.1.106 Tris - 317 3.2.1.106 Tris 20 mM: 50% inhibition 317 3.2.1.106 Tris/maleate 10 mM: 60% inhibition 44905 3.2.1.106 Trypsin up to 40% inhibition in the presence of Lubrol PX, without Lubrol PX: no inhibition 393 3.2.1.106 Zn2+ quite inhibitory 14 3.2.1.106 Zn2+ potent inhibitor, inhibition reversed by adding an excess of dithiothreitol 14