3.1.2.6 12-O-tetradecanoylphorbol-13-acetate - 3962 3.1.2.6 2,4,6-Trinitrobenzenesulfonate - 3303 3.1.2.6 2,4,6-Trinitrobenzenesulfonate N-acetyl-S-(p-bromobenzyl)glutathione protects 3303 3.1.2.6 2-aminopyridine - 20595 3.1.2.6 acidic phospholipids noncompetitive inhibition, lower thermal stability of the enzyme, inhibit protein intermolecular interactions/aggregation by thermal denaturation, small changes in the secondary structure are caused 9408 3.1.2.6 adenine - 144 3.1.2.6 adenosine - 122 3.1.2.6 ADP - 13 3.1.2.6 AMP - 30 3.1.2.6 aniline - 676 3.1.2.6 anionic phospholipids noncompetitive inhibition, cytosolic isozyme 31098 3.1.2.6 AsO2- - 7151 3.1.2.6 ATP - 4 3.1.2.6 benzimidazole - 1751 3.1.2.6 Caffeine - 882 3.1.2.6 cardiolipin negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction 813 3.1.2.6 Cd2+ the enzyme activity decreases by 20% and 32% at 0.5 and 1.0 mM Cd2+, respectively 52 3.1.2.6 CdCl2 - 906 3.1.2.6 CDP - 212 3.1.2.6 CMP - 100 3.1.2.6 coenzyme A - 534 3.1.2.6 copper acetate above 15 mM 102633 3.1.2.6 CTP - 60 3.1.2.6 Cu2+ - 19 3.1.2.6 cytidine - 372 3.1.2.6 D-lactate competitive inhibition 600 3.1.2.6 D-lactate - 600 3.1.2.6 diethyldicarbonate pH 6 310 3.1.2.6 diethyldicarbonate - 310 3.1.2.6 dioleoyl phosphatidic acid i.e. DOPA, negatively charged phospholipid, strongly inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction 12971 3.1.2.6 dipalmitoylphosphatidylserine negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction 53889 3.1.2.6 diphosphate 25 mM, 50% inhibition 17 3.1.2.6 DTT 1.25 mM, 60% inhibition 177 3.1.2.6 EDTA - 21 3.1.2.6 Fe2+ addition to the medium slightly reduces the activity in vivo 25 3.1.2.6 fructose inactivation of the glyoxalase system (glyoxalase I and II) in fructose fed mice 603 3.1.2.6 GDP - 53 3.1.2.6 glutathione - 44 3.1.2.6 glutathione weak competitive 44 3.1.2.6 glutathione a combination of methylglyoxal and glutathione has a greater than additive inhibitory activity 44 3.1.2.6 glutathione 8.0 mM, 43% loss of activity 44 3.1.2.6 glutathione non-competitive inhibition. Is a stronger inhibitor than the ethyl ester of glutathione. Theorell-Chance Bi Bi mechanism with glutathione as the second product 44 3.1.2.6 glutathione metal-selective end product inhibition. Thiol-Fe bond is formed between the Cys moiety of glutathione and the metal site, the dinuclear iron sites show an enhanced antiferromagnetic coupling in the GloB-glutathione adduct 44 3.1.2.6 glutathione ethyl ester carboxylate group of the glycine-moiety is modified, non-competitive inhibition 6957 3.1.2.6 GMP - 162 3.1.2.6 GSH - 142 3.1.2.6 GTP - 37 3.1.2.6 Guanidine-HCl below 1 M, inactivation occurs without loss of the secondary structure 1162 3.1.2.6 guanine - 199 3.1.2.6 guanosine - 296 3.1.2.6 hexyl-S-glutathione - 102877 3.1.2.6 Hg2+ - 33 3.1.2.6 Hg2+ HgCl2, most potent inhibitor 33 3.1.2.6 Hg2+ HgCl2, 0.5 mM, complete inhibition 33 3.1.2.6 Hg2+ HgCl2 33 3.1.2.6 iodoacetate - 93 3.1.2.6 KCl above 15 mM 79 3.1.2.6 methylene blue photoinactivation 512 3.1.2.6 methylglyoxal - 322 3.1.2.6 methylglyoxal-glutathione hemimercaptal - 13066 3.1.2.6 Mn2+ addition to the medium reduces the activity in vivo 11 3.1.2.6 additional information inhibitory effect of methanol-extracts of some edible plants and some medicinal herbs against the glyoxalase II 2 3.1.2.6 additional information benzyloxycarbonyl-S-derivatives are stronger inhibitors than the p-chlorophenacyl S-derivative 2 3.1.2.6 additional information the enzyme is not sensitive against ionic strength 2 3.1.2.6 additional information negatively charged phospholipids, like dioleoyl phosphatidic acid, cardiolipin, and phosphatidylserine, specifically interact with the enzyme, but do not inhibit the mitochondrial isozyme, no effect by neutral phospholipids 2 3.1.2.6 additional information no effect by neutral phospholipids, phospholipid binding studies 2 3.1.2.6 N,S-(dicarbobenzoxy)glutathione - 47987 3.1.2.6 N,S-bis-(9-fluorenylmethoxycarbonyl)glutathione - 17245 3.1.2.6 N,S-bis-(phenylmethoxycarbonyl)glutathione - 53892 3.1.2.6 N,S-bis-carbobenzoxy-glutathione - 147204 3.1.2.6 N,S-bis-FMOC-glutathione - 71522 3.1.2.6 N,S-bisfluorenylmethoxycarbonylglutathione - 47988 3.1.2.6 N-(9-fluorenylmethoxycarbonyl)-S-phenylmethoxycarbonylglutathione - 53895 3.1.2.6 N-(9-fluorenylmethoxycarbonyl)glutathione - 53890 3.1.2.6 N-acetyl-S-(p-bromobenzyl)glutathione competitive 16519 3.1.2.6 N-acetyl-S-(p-bromobenzyl)glutathione - 16519 3.1.2.6 N-benzoyl-S-(p-bromobenzyl)glutathione - 103140 3.1.2.6 N-benzyloxycarbonyl-S-(p-bromobenzyl)glutathione - 103150 3.1.2.6 N-phenylmethoxycarbonyl-S-(9-fluorenylmethoxycarbonyl)glutathione - 53896 3.1.2.6 N-phenylmethoxycarbonylglutathione - 53893 3.1.2.6 Na2HAsO4 0.5 mM arsenic decreases the enzyme activity by 29% 6567 3.1.2.6 NaCl above 15 mM 42 3.1.2.6 NEM - 89 3.1.2.6 NH4Cl above 15 mM 329 3.1.2.6 octyl-S-glutathione - 45791 3.1.2.6 oxalate 20 mM, 38% inhibition 185 3.1.2.6 p-hydroxymercuribenzoate - 98 3.1.2.6 p-nitrobenzyl-S-glutathione very weak 103405 3.1.2.6 PCMB 0.3 mM, complete inhibition 78 3.1.2.6 PCMB - 78 3.1.2.6 Phenylglyoxal 10 mM, 1 h, 60% loss of activity 301 3.1.2.6 Phenylglyoxal - 301 3.1.2.6 phosphate 67 mM, 35% inhibition 16 3.1.2.6 phosphatidylserine negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction 430 3.1.2.6 propyl-S-glutathione - 103557 3.1.2.6 pyridoxal - 608 3.1.2.6 pyridoxamine - 1284 3.1.2.6 S,N-blocked glutathiones - 103610 3.1.2.6 S-(9-fluorenylmethoxycarbonyl)glutathione - 53891 3.1.2.6 S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione - 7425 3.1.2.6 S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione competitive inhibition 7425 3.1.2.6 S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione 50% inhibition at 0.0016 mM; 50% inhibition at 0.02 mM 7425 3.1.2.6 S-(N-hydroxy-N-chlorophenylcarbamoyl)glutathione 50% inhibition at 0.002 mM; 50% inhibition at 0.03 mM 23739 3.1.2.6 S-(N-hydroxy-N-phenylcarbamoyl)glutathione 50% inhibition at 0.006 mM; 50% inhibition at 0.185 mM 35446 3.1.2.6 S-(p-Azidophenacyl)-glutathione linear competitive 45890 3.1.2.6 S-(p-Azidophenacyl)-glutathione - 45890 3.1.2.6 S-(p-azidophenacyl)glutathione - 58868 3.1.2.6 S-(p-bromobenzyl)glutathione - 20503 3.1.2.6 S-(p-chlorophenacyl)glutathione - 48143 3.1.2.6 S-benzyloxycarbonylglutathione - 13081 3.1.2.6 S-blocked glutathiones - 103622 3.1.2.6 S-fluorenylmethyloxycarbonylglutathione - 48145 3.1.2.6 S-hexylglutathione - 3094 3.1.2.6 S-m-nitrobenzyloxycarbonylglutathione - 21353 3.1.2.6 S-o-nitrobenzyloxycarbonylglutathione - 21354 3.1.2.6 S-p-nitrobenzyloxycarbonylglutathione potent competitive 9480 3.1.2.6 S-p-nitrobenzyloxycarbonylglutathione - 9480 3.1.2.6 S-phenylmethoxycarbonylglutathione - 53894 3.1.2.6 S-propylglutathione - 32958 3.1.2.6 Theobromine - 2761 3.1.2.6 theophylline - 1221 3.1.2.6 thymine - 438 3.1.2.6 transcription factor p63 upregulation of glyoxalase II 147202 3.1.2.6 transcription factor p73 upregulation of glyoxalase II 147203 3.1.2.6 Trinitrobenzenesulfonate - 6028 3.1.2.6 Trp - 817 3.1.2.6 UMP - 133 3.1.2.6 Uracil - 334 3.1.2.6 uridine - 261 3.1.2.6 UTP - 65 3.1.2.6 xanthine - 234