2.7.1.151 abscisic acid In ten-day-old seedlings grown on MS medium, AtIpk2b transcript level decreased. 1748 2.7.1.151 aurintricarboxylic acid mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, strong inhibition, IC50 is 44 nM 1818 2.7.1.151 chlorogenic acid mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 0.0012 mM 592 2.7.1.151 ellagic acid mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 0.0014 mM 1279 2.7.1.151 gossypol mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 0.0034 mM 1825 2.7.1.151 inositol(1,3,4)-trisphosphate potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM 62550 2.7.1.151 inositol(3,5,6)-trisphosphate IC50: 0.1 mM 62551 2.7.1.151 additional information inhibitory effects are not due to inactivating aggregation of the enzyme, no inhibition by quercetin, 3',4',7,8-tetrahydroxyflavone, myricetin, hypericin, epigallocatechin-3-gallate, and epicatechin-3-gallate, the enzyme contains a unique basic segment of 105 amino acids, which is inserted between the SSLL motif and the DFG motif, being probably involved in inhibition by acidic polyphenols 2 2.7.1.151 additional information no inhibition by wortmannin and LY294002 2 2.7.1.151 additional information an enzyme-deficient mutant strain is resistant to inhibition by wortmannin, while transformation with the wild-type enzyme reverses the effect 2 2.7.1.151 additional information IPMK3s phosphoinositide-3 kinase activity is distinguished from previously described phosphoinositide-3 kinase in its complete insensitivity to pharmacological inhibition by wortmannin, a potent inhibitor of canonical phosphoinositide-3 kinase.; selective hypersensitivity to rapamycin, an inhibitor of the TOP (target of rapamycin) kinases wit preeminent regulatory roles in general nitrogencatabolite repression control. 2 2.7.1.151 NaCl In ten-day-old seedlings grown on MS medium, AtIpk2b transcript level decreases in response to salt 42 2.7.1.151 Rose bengal mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 620 nM 1331 2.7.1.151 Wortmannin - 631