2.6.1.5 (4-hydroxyphenyl)acetic acid 74% inhibition with tyrosine at 3 mM and (4-hydroxyphenyl)acetic acid at 12 mM 10446 2.6.1.5 2-aminooxyacetate - 172051 2.6.1.5 2-chloro-3-(5-{[(2,6-difluorobenzyl)oxy]methyl}-5-methyl-4,5-dihydro-1,2-oxazol-3-yl)-6-(propan-2-yl)pyridine 1 mM: 79% inhibition of enzyme activity, 0.5 mM: 67% inhibition of enzyme activity, 0.25 mM: 44% inhibition of enzyme activity 172050 2.6.1.5 2-oxoglutarate substrate inhibition at high concentration 34 2.6.1.5 2-oxoglutarate enzyme shows substrate inhibition 34 2.6.1.5 3,4-dihydroxyphenylalanine - 1782 2.6.1.5 3,4-Dihydroxyphenyllactate strong inhibition of all the three TAT isoenzymes 20609 2.6.1.5 3-(3,4-Dihydroxyphenyl)-2-methylalanine - 29458 2.6.1.5 3-(5-{[(2,6-difluorobenzyl)oxy]methyl}-5-methyl-4,5-dihydro-1,2-oxazol-3-yl)pyridine-2-carbonitrile 1 mM: 82% inhibition of enzyme activity, 0.5 mM: 46% inhibition of enzyme activity, 0.25 mM: 8% inhibition of enzyme activity 172049 2.6.1.5 3-methoxydopamine - 91498 2.6.1.5 3-Methoxytyrosine - 43336 2.6.1.5 4-methylsulfonyl-2,5,6,2',4',5'-hexachlorobiphenyl significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0008 mM 125167 2.6.1.5 4-methylsulfonyl-2,5,6,2',4'-pentachlorobiphenyl significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0007 mM 125166 2.6.1.5 5-hydroxyindole acetic acid 55% inhibition with tyrosine at 3 mM and 5-hydroxyindole acetic acid at 12 mM 43544 2.6.1.5 5-hydroxytryptophan 30% inhibition with tyrosine at 3 mM and 5-hydroxytryptophan at 12 mM 2540 2.6.1.5 Ag2+ - 1041 2.6.1.5 AgNO3 10 mM, complete inhibition 360 2.6.1.5 alpha-Methyl-L-aspartate with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates 96130 2.6.1.5 alpha-Methyltyrosine - 43749 2.6.1.5 Aminooxyacetate probably acts reacting with the cofactor 1374 2.6.1.5 Aminooxyacetate 1 mM, complete inhibition 1374 2.6.1.5 beta-Methyl-L-aspartate with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates 92777 2.6.1.5 beta-phenylalanine enzyme shows substrate inhibition 88728 2.6.1.5 Ca2+ - 15 2.6.1.5 Canaline - 5532 2.6.1.5 Canaline probably acts reacting with the cofactor 5532 2.6.1.5 cinmethylin 0.5 mM: 96% inhibition of enzyme activity, 0.25 mM: 20% inhibition of enzyme activity 172047 2.6.1.5 CuSO4 10 mM, complete inhibition 263 2.6.1.5 D-Aspartate weak inhibition 634 2.6.1.5 D-tyrosine 9% inhibition with tyrosine at 3 mM and D-tyrosine at 12 mM 1643 2.6.1.5 Dextran sulfate dextran sulfate inhibits TAT activity but conditioned macrophage medium reliably increases enzyme activity in hepatocytes 2775 2.6.1.5 dihydroxymandelic acid 65% inhibition with tyrosine at 3 mM and dihydroxymandelic acid at 3 mM 93201 2.6.1.5 dihydroxyphenylacetic acid 88% inhibition with tyrosine at 3 mM and dihydroxyphenylacetic acid at 3 mM 29946 2.6.1.5 dopamine 100% inhibition with tyrosine at 3 mM and dopamine at 12 mM 242 2.6.1.5 EDTA 1 mM, 21% residual activity 21 2.6.1.5 Hg2+ - 33 2.6.1.5 homogentisate half-maximal inhibition with 15 micromolar 1826 2.6.1.5 homovanillic acid - 12554 2.6.1.5 indole-3-acetic acid 42% inhibition with tyrosine at 3 mM and indole-3-acetic acid at 12 mM 2965 2.6.1.5 indole-3-butyric acid 71% inhibition with tyrosine at 3 mM and indole-3-butyric acid at 12 mM 12559 2.6.1.5 Indole-3-propionic acid 48% inhibition with tyrosine at 3 mM and indole-3-propionic acid at 12 mM 6537 2.6.1.5 ketoconazole significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0011 mM 483 2.6.1.5 kynuric acid 10 mM, complete inhibition 125165 2.6.1.5 L-aspartate with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates 97 2.6.1.5 L-glutamate - 41 2.6.1.5 L-glutamate competitive inhibition 41 2.6.1.5 methiozolin 0.5 mM: 91% inhibition of enzyme activity, 0.25 mM: 57% inhibition of enzyme activity 172048 2.6.1.5 Mn2+ - 11 2.6.1.5 norepinephrine competitive inhibition 975 2.6.1.5 normetanephrine - 7260 2.6.1.5 phenylacetic acid 30% inhibition with tyrosine at 3 mM and phenylacetic acid at 12 mM 960 2.6.1.5 Phenylethylamine 80% inhibition with tyrosine at 3 mM and phenylethylamine at 12 mM 900 2.6.1.5 phenylhydrazine 1 mM, complete inhibition 398 2.6.1.5 rosmarinic acid isoenzymes TAT-2 and TAT-3 2035 2.6.1.5 serotonin 37% inhibition with tyrosine at 3 mM and serotonin at 12 mM 437 2.6.1.5 SnCl2 10 mM, complete inhibition 3228 2.6.1.5 sodium dodecylsulfate 1 mM, complete inhibition 1066 2.6.1.5 tolylfluanid significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0014 mM 125168 2.6.1.5 tyramine 13% inhibition with tyrosine at 3 mM and tyramine at 12 mM 280 2.6.1.5 Urea the enzyme shows a gradual decrease in the activity till 2.5 M urea, after which the complete loss of activity is measured 116 2.6.1.5 vanillylmandelic acid 51% inhibition with tyrosine at 3 mM and vanillylmandelic acid at 3 mM 30503 2.6.1.5 Zn2+ - 14