2.4.2.19 2-Hydroxynicotinate 50% at 0.01 M 29390 2.4.2.19 2-oxoglutarate 1 mM, 60% inhibition 34 2.4.2.19 2-oxoglutarate 1 mM, 55% inhibition 34 2.4.2.19 5-phospho-alpha-D-ribose 1-diphosphate substrate inhibition, mixed inhibition (competitive and non-competitive) above 0.3 mM 5-phospho-alpha-D-ribose 1-diphosphate 158 2.4.2.19 5-phosphoribosyl-1-diphosphate inhibition at alkaline pH and at physiological pH, pH 7.4, but not at an acidic pH, competitive for quinolinate. In presence of 30% glycerol, both the kidney and liver enzyme are inhibited, even at acidic pH 11242 2.4.2.19 5-phosphoribosyl-1-diphosphate - 11242 2.4.2.19 acetic acid 26% inhibition 751 2.4.2.19 ADP 2 mM, 25% inhibition 13 2.4.2.19 ADP 1 mM, 12% inhibition 13 2.4.2.19 Ag+ 1 mM, complete inhibition 75 2.4.2.19 Al3+ - 264 2.4.2.19 Al3+ 1 mM, 82.8% inhibition 264 2.4.2.19 AMP 2 mM, 7% inhibition 30 2.4.2.19 aspartic acid 1 mM, 23% inhibition 2947 2.4.2.19 aspartic acid 1 mM, 37% inhibition 2947 2.4.2.19 ATP 2 mM, 82% inhibition 4 2.4.2.19 ATP 2 mM, 82% inhibition; inhibition is removed by raising Mg2+ concentrations 4 2.4.2.19 ATP 1 mM, 22% inhibition; inhibition is completely recovered by raising Mg2+ concentration 4 2.4.2.19 Ba2+ 1 mM, 38.1% inhibition 111 2.4.2.19 Ca2+ 1 mM, 34.9% inhibition 15 2.4.2.19 Cd2+ 1 mM, 75.5% inhibition 52 2.4.2.19 Cd2+ - 52 2.4.2.19 CDP 2 mM, 20% inhibition 212 2.4.2.19 CDP 1 mM, 13% inhibition 212 2.4.2.19 Citric acid 1 mM, 95% inhibition 1714 2.4.2.19 Citric acid 1 mM, 89% inhibition 1714 2.4.2.19 Cl- - 141 2.4.2.19 Co2+ 1 mM, 65.2% inhibition 23 2.4.2.19 Co2+ - 23 2.4.2.19 Cr3+ 1 mM, 46.4% inhibition 895 2.4.2.19 CTP 2 mM, 77% inhibition 60 2.4.2.19 CTP 1 mM, 30% inhibition 60 2.4.2.19 Cu2+ 1 mM, 87% inhibition 19 2.4.2.19 Cu2+ 1 mM, 86.9% inhibition 19 2.4.2.19 Cu2+ - 19 2.4.2.19 D-fructose-1,6-diphosphate competitive with respect to 5-phosphoribosyl-1-diphosphate and noncompetitive with respect to quinolinate 10623 2.4.2.19 diphosphate noncompetitive with respect to both 5-phosphoribosyl-1-diphosphate and quinolinate 17 2.4.2.19 dipicolinic acid 1 mM, 24% inhibition 1443 2.4.2.19 dithiobis(2-nitrobenzoic acid) 10 mM, 88.7% inhibition 93233 2.4.2.19 dTDP 1 mM, 14% inhibition 542 2.4.2.19 dTTP 1 mM, 29% inhibition 145 2.4.2.19 Fe2+ - 25 2.4.2.19 Fe2+ 1 mM, 93% inhibition 25 2.4.2.19 Fe2+ 1 mM, 61.5% inhibition 25 2.4.2.19 Fe3+ - 70 2.4.2.19 Fe3+ 1 mM, 92.9% inhibition 70 2.4.2.19 formic acid 1 mM, 54% inhibition 4010 2.4.2.19 Fumaric acid 1 mM, 72% inhibition 6524 2.4.2.19 Fumaric acid 1 mM, 67% inhibition 6524 2.4.2.19 GDP 2 mM, 29% inhibition 53 2.4.2.19 glycerol inhibition increases as the pH raises 135 2.4.2.19 glycerol glycerol markedly activates enzyme activity at pH 6.1 and 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 135 2.4.2.19 GTP 2 mM, 77% inhibition 37 2.4.2.19 GTP 1 mM, 17% inhibition 37 2.4.2.19 H2PO4- - 30061 2.4.2.19 Hg2+ 1 mM, 99.9% inhibition 33 2.4.2.19 Hg2+ - 33 2.4.2.19 IDP 2 mM, 29% inhibition 444 2.4.2.19 IMP 2 mM, 6% inhibition 232 2.4.2.19 isocinchomeric acid 1 mM, 15% inhibition 113677 2.4.2.19 ITP 2 mM, 81% inhibition 229 2.4.2.19 ITP 1 mM, 24% inhibition 229 2.4.2.19 L-Glutamic acid 1 mM, 31% inhibition 1163 2.4.2.19 L-Glutamic acid 1 mM, 41% inhibition 1163 2.4.2.19 L-Malic acid 1 mM, 75% inhibition 5169 2.4.2.19 L-Malic acid 1 mM, 67% inhibition 5169 2.4.2.19 Lactic acid 1 mM, 29% inhibition 7226 2.4.2.19 lutidinic acid 1 mM, 17% inhibition 113750 2.4.2.19 Maleic acid 1 mM, 34% inhibition 4029 2.4.2.19 Maleic acid 1 mM, 42% inhibition 4029 2.4.2.19 methyl-3-amidopyridine-2-carboxylate - 113789 2.4.2.19 methyl-3-cyanopyridine 2-carboxylate - 113790 2.4.2.19 Mg2+ 1 mM, 7.7% inhibition 6 2.4.2.19 Mn2+ 1 mM, 80.3% inhibition 11 2.4.2.19 Monoiodoacetic acid 5 mM, 50% inhibition 2275 2.4.2.19 Monoiodoacetic acid 50 mM, 99.8% inhibition 2275 2.4.2.19 additional information nicotinic acid and nicotinamide inhibit growth of roots 2 2.4.2.19 Na4P2O7 3 mM, complete inhibition 30268 2.4.2.19 NAD+ 19% inhibition at 1 mM, 15% inhibition at 10 mM 7 2.4.2.19 NEM 5 mM, 86% inhibition 89 2.4.2.19 Ni2+ - 38 2.4.2.19 Ni2+ 1 mM, 76.5% inhibition 38 2.4.2.19 nicotinate mononucleotide competitive with respect to 5-phosphoribosyl-1-diphosphate 5194 2.4.2.19 nicotinate mononucleotide 1 mM, 46% inhibition 5194 2.4.2.19 nicotinate mononucleotide - 5194 2.4.2.19 NO3- - 673 2.4.2.19 oxaloacetic acid 1 mM, 56% inhibition 2862 2.4.2.19 oxaloacetic acid 1 mM, 59% inhibition 2862 2.4.2.19 PCMB 0.05 mM, complete inhibition 78 2.4.2.19 Phthalate - 2867 2.4.2.19 Phthalic acid competitive to quinolinate 3662 2.4.2.19 Phthalic acid dead-end inhibitor, competitive with respect to quinolinate, uncompetitive with respect to 5-phosphoribosyl-1-diphosphate 3662 2.4.2.19 Phthalic acid - 3662 2.4.2.19 Picolinic acid - 4859 2.4.2.19 Pyrazinamide - 3666 2.4.2.19 pyrazinoic acid - 21690 2.4.2.19 Sr2+ 47.6% inhibition 338 2.4.2.19 succinic acid 1 mM, 51% inhibition 2759 2.4.2.19 succinic acid 1 mM, 46% inhibition 2759 2.4.2.19 Tris - 317 2.4.2.19 UDP 2 mM, 32% inhibition 26 2.4.2.19 UTP 2 mM, 74% inhibition 65 2.4.2.19 UTP 1 mM, 19% inhibition 65 2.4.2.19 Zn2+ - 14 2.4.2.19 Zn2+ 1 mM, 82.1% inhibition 14