2.3.3.10 (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid i.e. F-244 134965 2.3.3.10 (E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid - 32767 2.3.3.10 (S)-3-hydroxy-3-methylglutaryl-CoA - 1835 2.3.3.10 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide - 3174 2.3.3.10 2-benzyl-9-(3,6-dioxocyclohexa-1,4-dienyl)-2,3,7,8-tetrahydro-6H-pyrido[1,2-a]pyrazine-1,4-dione - 155381 2.3.3.10 3,3-dimethylglutaryl-CoA - 104724 2.3.3.10 3-carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxyl-CoA - 32798 2.3.3.10 3-carboxypropionyl-CoA - 48590 2.3.3.10 3-chloropropionyl-CoA - 15528 2.3.3.10 3-hydroxy-3-methylglutaryl-CoA - 1271 2.3.3.10 3-oxohexanoyl-CoA - 6444 2.3.3.10 5,5'-dithiobis(2-nitrobenzoate) residual activity 51% 303 2.3.3.10 5,5'-dithiobis(2-nitrobenzoate) Ellman's reagent 303 2.3.3.10 5,5'-dithiobis(2-nitrobenzoate) - 303 2.3.3.10 acetoacetyl-CoA substrate inhibition 187 2.3.3.10 acetoacetyl-CoA - 187 2.3.3.10 acetoacetyl-CoA competitive inhibition 187 2.3.3.10 acetoacetyl-CoA inhibition of wild-type enzyme, no inhibition of mutant enzyme H188N and H188N/S259A 187 2.3.3.10 acetoacetyl-CoA potent inhibitor of the overall reaction 187 2.3.3.10 acetyloxy(phenyl)mercury phenyl mercuric acetate 155380 2.3.3.10 arsenite in presence of CoA, residual activity 25% 397 2.3.3.10 bromoacetyl-CoA - 20167 2.3.3.10 butyryl-CoA - 270 2.3.3.10 Cd2+ - 52 2.3.3.10 CdSO4 residual activity 9% 4508 2.3.3.10 Co2+ - 23 2.3.3.10 CoA - 18 2.3.3.10 CoA mixed product inhibition 18 2.3.3.10 Cu2+ - 19 2.3.3.10 decanoyl-CoA - 541 2.3.3.10 desulfo-CoA - 1409 2.3.3.10 diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate disulfiram 155379 2.3.3.10 DL-3-hydroxy-3-methylglutaryl-CoA uncompetitive inhibition 4332 2.3.3.10 DL-3-hydroxy-3-methylglutaryl-CoA mixed product inhibition 4332 2.3.3.10 DL-3-hydroxy-3-methylglutaryl-CoA - 4332 2.3.3.10 DL-3-hydroxy-3-methylglutaryl-CoA product inhibition 4332 2.3.3.10 DL-3-hydroxy-3-methylglutaryl-CoA competitive inhibition 4332 2.3.3.10 DL-3-methylglutaryl-CoA - 50699 2.3.3.10 F-244 IC50: 35 nM 56990 2.3.3.10 F-244 - 56990 2.3.3.10 F244 - 125121 2.3.3.10 glutaryl-CoA - 656 2.3.3.10 heptanoyl-CoA - 4253 2.3.3.10 hexanoyl-CoA - 395 2.3.3.10 hymeglusin IC50: 0.00032 mM, inhibitor binds to the thiol residue of Cys 13747 2.3.3.10 hymeglusin - 13747 2.3.3.10 hymeglusin i.e. (2E,4E,7R)-11-[(2R,3R)-3-(hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid, time-dependent loss of activity is observed with more than 95% inhibition achieved at extended incubation times (10 min at 75-600 nM) 13747 2.3.3.10 iodoacetamide residual activity 84% 67 2.3.3.10 iodoacetamide - 67 2.3.3.10 iodoacetate - 93 2.3.3.10 L-659,699 antibiotic 1233A 21911 2.3.3.10 L-659,699 potent inhibitor of the recombinant enzyme 21911 2.3.3.10 L-659,699 - 21911 2.3.3.10 Lifibrol - 45636 2.3.3.10 methanol - 83 2.3.3.10 Mg2+ mitochondrial enzyme 6 2.3.3.10 MgCl2 synthase I 196 2.3.3.10 MgCl2 mitochondrial enzyme 196 2.3.3.10 Mn2+ - 11 2.3.3.10 additional information desulfo-CoA protects against bromoacetyl-CoA inhibition, but not against p-chloromercuribenzoate and N-ethylmaleimide 2 2.3.3.10 additional information insensitive to feedback substrate inhibition by acetoacetyl-CoA 2 2.3.3.10 N-ethylmaleimide residual activity 46% 49 2.3.3.10 N-ethylmaleimide - 49 2.3.3.10 NaAsO2 residual activity 90% 4035 2.3.3.10 nonanoyl-CoA - 6571 2.3.3.10 octanoyl-CoA - 385 2.3.3.10 p-chloromercuribenzoate residual activity 16% 43 2.3.3.10 p-chloromercuribenzoate - 43 2.3.3.10 palmitoyl-CoA mitochondrial synthase 128 2.3.3.10 phenyl arsenious oxide in presence of CoA, residual activity 41%; residual activity 75% 50363 2.3.3.10 propionyl-CoA - 350 2.3.3.10 succinyl-CoA mitochondrial synthase, 50% inhibition 224 2.3.3.10 succinyl-CoA - 224 2.3.3.10 Zn2+ - 14