2.3.1.301	1-(1-bromoheptyl)-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid	compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks	254760	
2.3.1.301	1-(1-bromohexyl)-4-(4-[[(3,5-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid	compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks	254761	
2.3.1.301	1-(1-bromooctyl)-4-(4-[[(2,5-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid	compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks	254762	
2.3.1.301	1-(3-carboxypropyl)-4-[4-[(3,5-difluorophenyl)methoxy]phenyl]-1H-pyrrole-2-carboxylic acid	compound possesses good in vitro antimycobacterial activity, MIC value 12.5 microg/ml	254770	
2.3.1.301	1-([[(2-hydroxyethyl)disulfanyl]carbonyl]oxy)octane	-	254829	
2.3.1.301	1-[(3-chlorophenyl)methyl]-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid	compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks	254877	
2.3.1.301	1-[(4-chlorophenyl)methyl]-4-(4-[[(2,4-difluorophenyl)methyl]amino]phenyl)-1H-pyrrole-2-carboxylic acid	compound exhibits strong inhibition on the growth of Mycobacterium tuberculosis H37Rv at 2 and at 4 weeks	254891	
2.3.1.301	11-[[(decyldisulfanyl)carbonyl]oxy]undecanoic acid	-	254925	
2.3.1.301	11-[[(decyloxy)carbonyl]disulfanyl]undecanoic acid	-	254926	
2.3.1.301	2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol	-	255047	
2.3.1.301	2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol	-	255071	
2.3.1.301	2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol	-	255072	
2.3.1.301	2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione	-	255073	
2.3.1.301	2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol	-	255075	
2.3.1.301	2-(benzenesulfonyl)naphthalene-1,4-diol	-	255129	
2.3.1.301	2-(methanesulfonyl)naphthalene-1,4-diol	-	255139	
2.3.1.301	2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol	-	255140	
2.3.1.301	3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid	-	255338	
2.3.1.301	CoA decyldisulfide	-	255886	
2.3.1.301	CoA octyldisulfide	-	255888	
2.3.1.301	additional information	2-tosylnaphthalene-1,4-diol analogues are reversible inhibitors (30 nM-5 microM) of the Mycobacterium tuberculosis and Plasmodium falciparum FabH enzymes. The sulfonyl group and naphthalene-1,4 diol are required for activity against all enzymes but the toluene portion can be significantly altered. Inhibitors are also effective against Escherichia coli FabH, EC 2.3.1.180	2	
2.3.1.301	additional information	not inhibitory: cerulenin	2	
2.3.1.301	thiolactomycin	-	1569	
2.3.1.301	[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid	-	256380