1.5.5.2	2-Thenoyltrifluoroacetone	an inhibitor of Complex II, addition of TTFA significantly reduces PRODH/POX activity	5476	
1.5.5.2	5-ethylpentyl-barbituric acid	membrane-associated enzyme, not soluble enzyme	108501	
1.5.5.2	acetate	competitive	47	
1.5.5.2	antimycin A	very strong inhibition	1042	
1.5.5.2	cyanide	only membrane-associated enzyme, not soluble enzyme	118	
1.5.5.2	D-lactate	-	600	
1.5.5.2	D-lactate	a competitive inhibitor of ProDH in plants	600	
1.5.5.2	GuHCl	enzyme unfolding at 1 M, 0.5 M is not enough for proper unfolding. The fusion protein forms visible aggregates due to unfolding of MBP	220825	
1.5.5.2	KCN	very strong inhibition	161	
1.5.5.2	L-azetidine-2-carboxylate	competitive	44300	
1.5.5.2	L-lactate	-	403	
1.5.5.2	L-lactate	competitive	403	
1.5.5.2	L-lactate	a competitive inhibitor of ProDH in plants	403	
1.5.5.2	L-proline	substrate inhibition at high L-proline concentrations; substrate inhibition at high L-proline concentrations	243	
1.5.5.2	L-proline	substrate inhibition at high L-proline concentrations	243	
1.5.5.2	L-tetrahydro-2-furoic acid	competitive	9812	
1.5.5.2	L-tetrahydro-2-furoic acid	-	9812	
1.5.5.2	L-thiazolidine-4-carboxylate	competitive	50074	
1.5.5.2	Lactate	-	1219	
1.5.5.2	additional information	no enzyme inhibibtion by atpenin A5, an inhibitor of Complex II	2	
1.5.5.2	N-propargylglycine	irreversibly inactivates PutA by covalently linking the flavin N(5) atom to the epsilon-amino of Lys329. Inactivation locks PutA into a conformation that may mimic the proline-reduced, membrane-associated form	37731	
1.5.5.2	pyrrolidone-5-carboxylate	-	220824	
1.5.5.2	pyruvate	-	31	
1.5.5.2	rotenone	an inhibitor of Complex I, addition of ROT only modestly affects PRODH/POX activity	777	
1.5.5.2	succinate	uncompetitive inhibitor, in the presence of low levels of proline in vivo, higher levels of succinate can act to inhibit PRODH/POX activity and reactive oxygena species generation. The affinity of succinate is for the enzyme-substrate complex of PRODH/POX and proline rather than for the enzyme binding site for proline. Succinate protects electron transport chain component proteins from PRODH/POX reactive oxygen species-mediated downregulation with almost the same efficacy as 3,4-dehydro-L-proline and N-acetyl-L-cysteine	58	
1.5.5.2	thiazolidine-2-carboxylate	a mechanism-based inactivator of PRODH. PRODH catalyzes the oxidation of thiazolidine-2-carboxylate at the C atom adjacent to the S atom of the thiazolidine ring (C5). Then, the N5 atom of the reduced FAD attacks the C5 of the oxidized T2C species, resulting in a covalent adduct	45933