1.14.19.3 4-chloro-5-dimethylamino-2-phenyl-3(2H)-pyridazinone BASF 13-338, San 9785, herbicide known to reduce levels of linolenic acid, inhibits in vitro desaturation of fatty acids 49806 1.14.19.3 bathophenanthroline sulfonate mild inhibition 7154 1.14.19.3 beta-mercaptoethanol mild inhibition 773 1.14.19.3 cholesterol - 189 1.14.19.3 conjugated linoleic acid all CLA isomers inhibits significantly the activity of DELTA6-desaturase, the c9,t11 isomer is the most potent inhibitor 32608 1.14.19.3 CP-24879 the combined DELTA5 desaturase/DELTA6 desaturase inhibitor significantly reduces intracellular lipid accumulation and inflammatory injury in hepatocytes 151064 1.14.19.3 dithiothreitol mild inhibition 45 1.14.19.3 iron chelators - 12928 1.14.19.3 KCN - 161 1.14.19.3 additional information aging, diabetes, viral infection, high alcohol intake, high level cholesterol, high blood pressure, radiation, stress-related hormones, deficiencies of zinc, magnesium, biotin, the vitamins C, B6, and B3, and excessive level of trans fatty acid reduce the enzyme activity in vivo 2 1.14.19.3 N-ethylmaleimide only little effect 49 1.14.19.3 N-ethylmaleimide n-3 DELTA6-desaturase is not inhibited, it increases, NEM specifically inhibits DELTA6-desaturase activity in the n-6 series, but not in the n-3-series 49 1.14.19.3 N-ethylmaleimide - 49 1.14.19.3 p-chloromercuribenzene sulfonate - 3222 1.14.19.3 saturated fatty acids - 31086 1.14.19.3 Tiron - 1881 1.14.19.3 trans-fats - 143518