1.5.1.22 additional information the enzyme activity in adductor muscle decreases following the marine-brackish gradient 2 1.5.1.22 oxaloacetate - 57 1.5.1.22 pyruvate inhibited by an excess of substrate pyruvate; substrate inhibition, in excess, pyruvate enters in competition with the other substrate (glycine and/or NADH) preventing the site of reaction to take all the substrates to proceed with the enzymatic reaction. Its optimal concentration is determined to be round 2.0-2.3 mM 31 1.5.1.22 succinate weak 58 1.5.1.22 succinate - 58