7.4.2.2 methylprednisolone stimulates Na-alanine cotransport in the normal intestine, mechanism of stimulation is secondary to an increase in cotransporter numbers without an alteration in the affinity for the amino acid. Treatment with MP reverses the reduction in Na-alanine cotransport in villus cells from the chronically inflamed intestine, secondary to restoration in the affinity for the amino acid without a change in the Vmax, overview 684325