2.7.11.15 (-)-Epinephrine requirement, agonist, alpha2-adrenergic receptor as substrate 645000 2.7.11.15 AlF4- enhances beta-ARK activity upon stimulation of heterotrimeric G proteins 645026 2.7.11.15 alpha2A-adrenergic receptor epinephrine-activated alpha2A-adrenergic receptor activates GRK2, interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction utilizing recombinant GST-tagged wild-type and several mutant alpha2A ARs, residues R225, R226, R218, K320, R322, and K358 are important, overview 662332 2.7.11.15 arrestins arrestins modulate the enzyme activity having a regulatory role, regulation of arrestins, overview 662911 2.7.11.15 beta-arrestin required for phosphorylation activity and receptor substrate endocytosis 662153 2.7.11.15 beta-arrestin-2 forms a complex with GRK3 causing G protein-coupled receptor desensitization 662131 2.7.11.15 beta-arrestin-2 required, membrane protein 661684 2.7.11.15 beta-arrestin2 mediates GRK activity, forms a signaling complex with filamin and dopamine D3 receptor, interactions, overview 662345 2.7.11.15 beta2-adrenergic receptor interaction of beta-ARK 1 with the agonist-occupied receptor activates 645028 2.7.11.15 beta2-adrenergic receptor interaction of enzyme with human agonist-occupied receptor specifically and significantly enhances peptide phosphorylation, at lower concentrations, enhances both the affinity and catalytic efficiency for peptide phosphorylation 645012