2.4.1.255 Ataxin-10 Atx-10 increases OGT activity 2fold 674603 2.4.1.255 Ataxin-10 encoded by the SCA10 (spinocerebellar ataxia type 10) gene, interacts with O-GlcNAc transferase OGT in pancreatic beta cells 657790 2.4.1.255 CoCl2 stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 D-glucose immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose 701898 2.4.1.255 dithiothreitol increases the activity of wild type OGT 659497 2.4.1.255 ethanol stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 H2O2 stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 hyperglycemia increases O-GlcNAc levels in pancreatic beta cells, which appears to interfere with beta-cell function 657790 2.4.1.255 Insulin tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment 693100 2.4.1.255 additional information beginning 12 h after treatment, glucose deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mM) 704458