2.1.1.17 1-methyl-4-phenylpyridinium enhances activity. S-Adenosylmethionine hypermethylation can be involved in the etiology of Parkinson‘s disease and an increase of phospholipid methylation could be one of the mechanisms by which 1-methyl-4-phenyl-pyridinium causes parkinsonism 485188 2.1.1.17 betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, the effect is enhanced by ethanol, which alone has no effect on expression levels of the enzyme, overview 675185 2.1.1.17 ethanol enhances the inducing and protecting effects of betaine on the enzyme, alone has only a slightly activating effect on the enzyme activity, overview 675185 2.1.1.17 L-Cys enhances activity, optimal concentration 10 mM 485175, 485176 2.1.1.17 additional information 17-beta-estradiol induces the enzyme in hepatocytes 697842 2.1.1.17 additional information light-activation is mediated by transducin 485194 2.1.1.17 progesterone physiological levels of progesterone activate PE-NMT and sphingomyelin synthase 719189 2.1.1.17 Triton X-100 enhances activity, optimal concentration 0.04% 485175, 485176 2.1.1.17 Tween 20 stimulates 485190