1.14.14.25 cholesterol 3-sulfate i.e. CH-35 689814 1.14.14.25 efavirenz EFV, activates the enzyme pharmacologically as a potential target for Alzheimers disease 736502 1.14.14.25 lovastatin induces and activates the enzyme, acts neuroprotectively in hippocampus after kainate injury, overview 675535 1.14.14.25 additional information cortical injury increases cholesterol 24S hydroxylase levels in the rat brain, overview 688555 1.14.14.25 additional information pharmaceuticals activate CYP46A1 allosterically through binding to the site on the cytosolic protein surface, which is different from the enzyme active site facing the membrane 736502