7.2.2.13 1-chloro-2,4-dinitrobenzene increase of the hydrolytic activity of the Na/K ATPase 671274 7.2.2.13 4-aminobutyric acid hypothesis: stimulate Na+/K+ transport via specific receptor inputs 672864 7.2.2.13 8-pCPT-CGMP induces a concentration-dependent increase in pump current, activator of PKG 675720 7.2.2.13 aldosterone control of Na,K-ATPase activity and expression 677134 7.2.2.13 Baclofen hypothesis: stimulate Na+/K+ transport via specific receptor inputs 672864 7.2.2.13 beta-catenin expression of beta-catenin significantly enhances the ouabain-sensitive current of the endogeneous Na+/K+-ATPase. beta-Catenin does not significantly modify the retrieval of the Na+/K+ ATPase from the cell membrane. The stimulating effect of beta-catenin on both Na+/K+ ATPase and Na+-coupled glucose transporter SGLT1 activity is observed even in the presence of actinomycin D 718740 7.2.2.13 dephostatin - 675517 7.2.2.13 desipramine inhibitor of adrenalin uptake and antidepressive action. Treatment differentially enhances the activity of Na+K+-ATPase alpha isoforms 688762 7.2.2.13 dexamethasone postnatal treatment of lamb with 0.5 mg per kg results in 21.4% increase in Na+K+-ATPase activity and a 30.4% increase in catalytic subunit alpha1 expression in the cerebral cortex. Treatment is not associated with significant changes in subunit beta1 expression. In the kidney, dexamethasone treatment is not associated with significant changes in enzyme activity, or alpha-1- or beta-1-isoform expression 690001 7.2.2.13 epinephrine hypothesis: stimulate Na+/K+ transport via specific receptor inputs 672864 7.2.2.13 glyburide presence of 5 mM ATP, slightly stimulating up to 1 mM, inhibitory above. Presence of 0.05 mM ATP, stimulating at least up to 3 mM 688954 7.2.2.13 Insulin control of Na,K-ATPase activity and expression 677134 7.2.2.13 interleukin-2 increases transport activity of the Na/K pump and the content of Na,K-ATPase alpha1 protein 673611 7.2.2.13 K+ extracellular 675517 7.2.2.13 lauric acid presence of 5 mM ATP, inhibitory above 0.25 mM. Presence of 0.05 mM ATP, stimulating up to 0.3 mM, inhibitory above 688954 7.2.2.13 Lyn kinase Lyn kinase directly binds to the Na+,K+-ATPase alpha3 subunit for regulation of activity 675517 7.2.2.13 monoclonal antibody SSA 78 - 696017 7.2.2.13 additional information half activated by a membrane potential of about -65 mV 246953 7.2.2.13 additional information increase in extracellular pH potentiates Na+-K+ pump activity 671273 7.2.2.13 additional information the alpha-subunit is 2-fold more abundant in seawater-acclimated salt glands than in freshwater-acclimated glands. There is no increase in the specific activity of NKA in seawtaer-acclimated animals and the in vitro rate of oxygen consumption by salt gland slices from seawater-acclimated animals is not significantly different from that of Ffreshwater-acclimated animals 720120 7.2.2.13 additional information the distal tube and collecting duct cells show more intense Na+/K+-ATPase immunoreaction in freshwater eel than in seawater-acclimated eel 720153 7.2.2.13 additional information The Na+-affinity is higher in oxidative muscle compared with glycolytic muscle and in purified membranes from oxidative muscle compared with glycolytic muscle 720204 7.2.2.13 NH4+ stimulation, following a single saturation curve. Synergistic effects of K+ and NH4+. At elevated concentrations of NH4+, enzyme is fully active and K+ cannot displace NH4+ from its exclusive binding sites 686204 7.2.2.13 NH4+ stimulation, following a single saturation curve. Synergistic effects of K+ and NH4+. Km value 4.5 mM 686200 7.2.2.13 NH4+ stimulation, synergistic effect of NH4+ and K+. Enzyme exhibits a single K+ binding site, NH4+ binding to a second, exlcusive site 686205 7.2.2.13 norepinephrine hypothesis: stimulate Na+/K+ transport via specific receptor inputs 672864 7.2.2.13 Ouabain activates Na/K-ATPase signaling complex 675880 7.2.2.13 Ouabain pretreatment of HK-2 cells with ouabain increases the Na+K+ATPase activity and inhibits the inhibitory effect of the D1 receptor on enzyme levels and activity, overview 711774 7.2.2.13 polyclonal antibody pSSA 78 - 696017 7.2.2.13 sodium control of Na,K-ATPase activity and expression by intracellular Na+ 677134 7.2.2.13 sodium nitroprusside SNP, NO donor, not a simple concentration-dependent effect on pump current 675720 7.2.2.13 Vasopressin control of Na,K-ATPase activity and expression 677134 7.2.2.13 YC-1 activator of soluble guanylyl cyclase, sGC 675720 7.2.2.13 Yes kinase regulator of the Na+,K+-ATPase activity 675517