2.7.11.27	adiponectin	adiponectin increases the phosphorylation and activation of AMPK, it increases inactivated acetyl-CoA carboxylase (ACC), which has been phosphorylated by activated AMPK, and subsequently increases expression of agouti-related peptide (AgRP) mRNA	740990	
2.7.11.27	AMP	-	640774, 741308, 760778, 761916	
2.7.11.27	AMP	activates ACK3, no effect on ACK2	640769	
2.7.11.27	AMP	activation of ACK3 with Ka: 0.5 mM	640770	
2.7.11.27	AMP	no effect	640771	
2.7.11.27	ATP	-	640765	
2.7.11.27	ATP	required	134902	
2.7.11.27	cAMP	-	693951, 694169	
2.7.11.27	cAMP-dependent protein kinase	phosphorylates and activates carboxylase kinase	640766	
2.7.11.27	CoA	inhibitory	640767	
2.7.11.27	CoA	most effective at 0.1 mM	640764	
2.7.11.27	CoA	no effect	640771	
2.7.11.27	CoA	required	640766	
2.7.11.27	CoA	required, activates exclusively activity towards acetyl-CoA carboxylase, Ka: 0.025 mM, binds to carboxylase not to kinase	640765	
2.7.11.27	CTRP1 protein	activates AMP-activated protein kinase (AMPK), which inhibits acetyl-CoA carboxylase (ACC) through phosphorylation. CTRP1 has a direct effect on AMPK signaling, recombinant CTRP1 administration acutely stimulates muscle AMPKalpha and ACC phosphorylation in vivo	740699	
2.7.11.27	deamino-CoA	-	640765	
2.7.11.27	dephospho-CoA	-	640765	
2.7.11.27	fructose	acetyl-CoA carboxylase phosphorylation by the enzyme increases significantly and concentration-dependently in fructose-treated HepG2 cells in the presence of placental lactogen	760778	
2.7.11.27	Insulin	-	640772, 640775	
2.7.11.27	leptin	stimulates fatty acid oxidation via the phosphorylation of AMPK and acetyl-CoA carboxylase, the stimulation by leptin is muscle fibre type-dependent and fails in diet-induced obesity	694169	
2.7.11.27	metformin	an AMPK activator	740545	
2.7.11.27	additional information	AMPK is activated in response to metabolic stresses, such as hypoxia and ischemia, and the anti-diabetic drug metformin	741308	
2.7.11.27	additional information	cAMP independent	134902, 640764, 640771	
2.7.11.27	additional information	covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids, activation by an unknown fatty acid-driven signalling process	661636	
2.7.11.27	oxidized CoA	-	640765