2.7.10.2 alboaggregin-A Trimeresurus albolabris venom, activates Fyn activity and translocation 662139 2.7.10.2 AMpYSSV CBP-based phosphopeptide, activates 661180 2.7.10.2 angiotensin subtype 1 receptor AT-1 receptor 691143 2.7.10.2 Ca2+ G-protein coupled receptor PAC1 regulates the tyrosine phosphorylation of isoform PYK2 in NCI-H838 nonsmall cell lung cancer cells. PYK2 phosphorylation is dependent upon Ca2+. The ability of PAC1 to regulate PYK2 is dependent on phospholipase and Src, and partially dependent on proteinkinase C 723012 2.7.10.2 CD45 transmembrane receptor-like protein tyrosine phosphatase activating the SFK by dephosphorylation of the regulatory tyrosine residue 661273 2.7.10.2 CX3CL1 i.e. fractalkine, only member of the delta subclass of chemokines, induces Syk activity in cytoskeletal remodeling 662575 2.7.10.2 CXCL12 - 738741 2.7.10.2 cytokine receptors - 672954 2.7.10.2 Epidermal growth factor - 690368 2.7.10.2 Epidermal growth factor activates fyn 672975 2.7.10.2 Epidermal growth factor EGF 691143 2.7.10.2 Epidermal growth factor epidermal growth factor increases levels of tyrosine phosphorylation of Jak2 702439 2.7.10.2 epidermal growth factor receptor the Abl nonreceptor tyrosine kinase is activated by ligand-stimulated EGFR 674681 2.7.10.2 epithelial growth factor receptor - 694492 2.7.10.2 EPQYEEIPIYL a src kinase activating peptide, binds to the SH2 domain of the src-kinase and activates it, activation of endogenous src-PTKs does not inhibit Kv1.3 channels in T lymphocytes, overview 675624 2.7.10.2 erythropoietin activates Fps/Fes tyrosine kinase 661671 2.7.10.2 H2O2 increases tyrosine phosphorylation in vivo, genistein decreases the activating effect 661445 2.7.10.2 insulin-like growth factor 1 receptor - 694492 2.7.10.2 interleukin 5 activates Janus kinases JAK1 and JAK2 704787 2.7.10.2 interleukin-2 enzyme activation in leukemic bone marrow cells 661859 2.7.10.2 lipopolysaccharide - 691455 2.7.10.2 lipopolysaccharide LPS 693456 2.7.10.2 Lyn kinase as part of the activation process Lyn phosphorylates Btk in Tyr551, which is subsequently autophosphorylated in Tyr223 691876 2.7.10.2 lysophosphatidic acid activates fyn 673700 2.7.10.2 macrophage antigen-1 i.e. Mac1, a beta2-integrin activates Src PTKs Hck and Lyn, interaction of both requires Mn2+ 660970 2.7.10.2 additional information a treatment of leukemic bone marrow cells with a mixture of interleukin-2, interferon-gamma, and non-specific BRM sheep erythrocytes leads to an increase in enzyme activity 661859 2.7.10.2 additional information Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions. High-affinity SH3 ligands can compete for these interactions and specifically activate the Abl kinase 490058 2.7.10.2 additional information activation loop structure of Src and of Csk, autophosphorylation sites 660885 2.7.10.2 additional information activation mechanism, autophosphorylation of Tyr551 causes a 10-fold increase in BTK activity 674905 2.7.10.2 additional information activation of Lck by prolonged hypoxia leading to increased phosphorylation of Kv1.3 channels 675624 2.7.10.2 additional information Akt is activated by phosphorylation at Ser473 and at Thr308 675205 2.7.10.2 additional information all-trans retinoic acid alters PTK activity and rhythm characteristics, period and amplitude of activity oscillations, overview 662838 2.7.10.2 additional information autophosphorylation of Y416 leads to the activation of c-Src 695228 2.7.10.2 additional information brain-derived neurotrophic factor BDNF induces the association and colocalization of TrkB with the lipid raft-resident protein Fyn, in situ study 675549 2.7.10.2 additional information Btk activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate 693466 2.7.10.2 additional information c-Abl is regulated also by phosphorylation 691143 2.7.10.2 additional information cellular counterpart of the viral v-fms oncogene product, the c-fms product, is the receptor for colony-stimulating factor 1 of macrophages, CSF-1. CSF-1 appeares to activate the serine/threonine kinase 490099 2.7.10.2 additional information constitutive SFK activation is associated with tumorigenesis, Hck and Lyn perform autophosphorylation for activation 674685 2.7.10.2 additional information Csk and CHK require conserved hydrophobicity in the SH2-kinase linker for catalytic activity 661726 2.7.10.2 additional information Csk is tyrosine autophosphorylated in the activation loop, structure 662138 2.7.10.2 additional information deoxygenation of SS cells increases Syk and Lyn PTK activities, overview 663021 2.7.10.2 additional information different activation mechanisms for Jak2 672954 2.7.10.2 additional information enzyme activity is induced by interleukin-8 in polymorphonuclear cells 660970 2.7.10.2 additional information FAK and PYK2 are activated in response to motogenic and mitogenic factors by phosphorylation and autophosphorylation 673223 2.7.10.2 additional information FAK is activated by autophosphorylation at Y397 693712 2.7.10.2 additional information hypoxia/reoxygenation induces tyrosine phosphorylation of Lck and Lck activity in breast cancer cells and of IkappaBalpha, but not of IkappaBalpha serine phosphorylation, activation is inhibited by emodin and pp2 662172 2.7.10.2 additional information ILK activity is rapidly, but transiently, stimulated upon attachment of cells to fibronectin, as well as by insulin, in a phosphoinositide-3-OH kinase-dependent manner. Furthermore, phosphatidylinositol(3,4,5)trisphosphate specifically stimulates the activity of ILK in vitro, and in addition, membrane targeted constitutively active Pi(3)K activates ILK in vivo 491056 2.7.10.2 additional information Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases 490629 2.7.10.2 additional information JAK2 activation loop structure, residues 994-1023, with phosphorylation sites Y1007 and Y1008, JAK2 switches between active and inactive forms involving the switch motif Asp994-Phe2995-Gly996 proximal to the active site, overview 661392 2.7.10.2 additional information nerve injury induces the activation of Src family kinases, Lyn is the predominant kinase 692517 2.7.10.2 additional information phosphorylation of Etk on Y40 is required for Etk activation 693455 2.7.10.2 additional information phosphorylation of the autoactivation tyrosine residue leads to activation of SFK, displacement of the PPII linker from the SH3 domain and the regulatory tyrosine residue from the SH2 domain, activation mechanisms, overview 661273 2.7.10.2 additional information phosphorylation of Tyr397 in Lyn results in activation of the enzyme 693239 2.7.10.2 additional information phosphorylation of Tyr418 is responsible for c-Src activation 694084 2.7.10.2 additional information phosphorylation of Y245 and Y412 leads to the activation of Abl kinase 694492 2.7.10.2 additional information protein kinase activation through an intra-molecular autophosphorylation process 692069 2.7.10.2 additional information PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, overview 673110 2.7.10.2 additional information SFK members are activated by phosphorylation and autophosphorylation 693712 2.7.10.2 additional information SH2-Bb and dimerized receptors synergistically promote Jak2 trans-activation in the context of intracellular signaling, SH2-B and receptor dimers constitute a bipolar clamp that stabilizes the active configuration of two Jak2 molecules in the same macro-complex 706405 2.7.10.2 additional information Src is activated by mechanical stretch of beta1 integrin, cell swelling and integrin clustering 662555 2.7.10.2 additional information Syk is activated by phosphorylation 672781 2.7.10.2 additional information Tec activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate 693466 2.7.10.2 additional information Tec family tyrosine kinase is activated by tyrosine phosphorylation 661230 2.7.10.2 additional information the enzyme is activated by phosphorylation, and also performs autophosphorylation 672104 2.7.10.2 additional information the enzyme performs self-activation by autophosphorylation at tyrosine residues 671209 2.7.10.2 additional information the leukemia inhibitory factor LIF and other growth factors are linked to Src family kinase activation 662918 2.7.10.2 additional information tyrosine phosphorylation and association of ZAP-70 with zeta require the presence of src family PTKs 490447 2.7.10.2 N,N'-ethylnitrosourea enzyme activation in leukemic bone marrow cells 661859 2.7.10.2 NGF rapidly stimulates both Ser and Thr phosphorylation in vivo and autophosphorylation activity in vitro of the B-Raf protein 492059 2.7.10.2 non-specific BRM sheep erythrocyte BRM is biological response modifier, treatment leads to a slight enzyme activation in leukemic bone marrow cells 661859 2.7.10.2 pervanadate activation of isoform Fer by reactive oxygen species causes increased phosphorylation of RhoGDIalpha, regulator of the small GTPase Rac, and pervanadate treatment further augmented this 721928 2.7.10.2 platelet-derived growth factor PDGF 691143 2.7.10.2 platelet-derived growth factor receptor - 694492 2.7.10.2 prolactin activates Jak2 674865 2.7.10.2 pseudolaric acid B pseudolaric acid B, PAB, activates PTK to induce apoptosis 690302 2.7.10.2 reactive oxygen species activation of isoform Fer by reactive oxygen species causes increased phosphorylation of RhoGDIalpha, regulator of the small GTPase Rac, and pervanadate treatment further augmented this 721928 2.7.10.2 Reelin extracellular, stimulates disabled-1 adaptor protein Dab1 tyrosine phosphorylation by Src family PTKs, downregulates Dab1 expression in vivo 662848 2.7.10.2 sphingosylphosphorylcholine activates fyn 673700 2.7.10.2 Src activated Src kinase in aggressive breast cancer cell lines can activate c-Abl kinase 694492 2.7.10.2 stem cell factor SCF activates Fps/Fes tyrosine kinase 661671 2.7.10.2 transforming growth factor beta receptor TGF-beta receptor 691143 2.7.10.2 tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors 672954