2.4.2.30	3-amino-1-methyl-5H-pyrido[4,3-b]indole	i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM	675627	
2.4.2.30	4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide	activates in presence of Mg2+, inhibits in absence of Mg2+	637997	
2.4.2.30	ATP	5-10 mM, 20-30% stimulation	637995	
2.4.2.30	Bmh1p	a yeast homologue of the human FAS, acts as an activating ExoS cofactor, overview	694800	
2.4.2.30	DNA	absolute requirement	637991, 637993	
2.4.2.30	DNA	enzyme has an N-terminal binding domain	638000	
2.4.2.30	DNA	required	637998	
2.4.2.30	DNA	slightly increases activity	725600	
2.4.2.30	DNA	the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1	637999	
2.4.2.30	FAS	exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS	662089	
2.4.2.30	GDP	increases activity in absence of Mg2+	637994	
2.4.2.30	GTP	increases activity in absence of Mg2+	637994	
2.4.2.30	GTP(gammaS)	increases activity in absence of Mg2+	637994	
2.4.2.30	harmaline hydrochloride	activates more strongly in absence of Mg2+ than in presence of Mg2+	637997	
2.4.2.30	Mg2+	5 mM, 6.3fold activation	725034	
2.4.2.30	additional information	DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview	672969	
2.4.2.30	additional information	in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity	662087	
2.4.2.30	additional information	PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death	671255	
2.4.2.30	additional information	stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, clone KIAA0827/amino acids 1-547, in HEK-293 cells increases the expression of the enzyme	671265	
2.4.2.30	oligodeoxyribonucleotides	slightly enhance enzyme activity with the maximal increase of 50% as compared to the control	725600	
2.4.2.30	peptide 14-3-3beta	-	736518	
2.4.2.30	Phenanthroline	0.1 mM, 1.1fold activation	725034	
2.4.2.30	Phthalic acid	activates more strongly in absence of Mg2+ than in presence of Mg2+	637997	
2.4.2.30	protein 14-3-3	dependent on	672996	
2.4.2.30	protein 14-3-3	required, interaction analysis, interaction equires residues L426, D427, and L428, overview, binding study of mutant enzymes, overview	673573