2.4.1.255 Ataxin-10 Atx-10 increases OGT activity 2fold 674603 2.4.1.255 Ataxin-10 encoded by the SCA10 (spinocerebellar ataxia type 10) gene, interacts with O-GlcNAc transferase OGT in pancreatic beta cells 657790 2.4.1.255 CoCl2 stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 D-glucose immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose 701898 2.4.1.255 dithiothreitol increases the activity of wild type OGT 659497 2.4.1.255 ethanol stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 H2O2 stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 hyperglycemia increases O-GlcNAc levels in pancreatic beta cells, which appears to interfere with beta-cell function 657790 2.4.1.255 Insulin tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment 693100 2.4.1.255 additional information beginning 12 h after treatment, glucose deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mM) 704458 2.4.1.255 additional information GPX1 activity is increased about 0.5fold by OGT 702092 2.4.1.255 additional information insulin signaling stimulates tyrosine phosphorylation of OGT, increases its catalytic activity, affects OGT localization, and results in the O-GlcNAc modification of STAT3, a key kinase and transcription factor in 3T3-L1 adipocytes 693100 2.4.1.255 additional information nearly all of the peptides became better acceptors as the concentration of UDP-GlcNAc increased with the exception of the YSPTSPSYSPTSPS 704392 2.4.1.255 NaCl stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate inhibitor of O-GlcNAcase, increase of the level of O-GlcNAc modifications 703439 2.4.1.255 sodium arsenite stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 UDP-N-acetyl-D-glucosamine - 723564 2.4.1.255 UVB light stress treatment induces higher levels of OGT protein expression 659361 2.4.1.255 vanadate tyrosine phosphatase inhibitor sodium vanadate, treatment increases OGT activity. When insulin is added to cells preincubated with sodium vanadate, there is a further increase in OGT activity versus inhibitor alone 693100