2.1.1.13	aquacob(III)alamin	the addition of 0.05 mM aquacob(III)alamin to the crude extract results in an about 13fold increase in activity which is not greatly affected by the addition of cytochrome P450 reductase or reductase domain of neuronal nitric oxide synthase	703638	
2.1.1.13	cadaverine	up to 40% stimulation at 1 mm	441207	
2.1.1.13	cyanocobalamin	supports methyltransferase in extracts of animal tissues and Escherichia coli	441196	
2.1.1.13	K+	at 67 mM 1.4 fold activity	441179	
2.1.1.13	Li+	at 67 mM, 1.3fold activity	441179	
2.1.1.13	methionine synthase reductase	restores the activity of human methionine synthase through reductive methylation of methionine synthase-bound cob(II)alamin. Oxidized methionine synthase reductase does not reactivate methionine synthase, the presence of methionine synthase reductase along with AqCbl or MeCbl causes a dramatic increase in methionine synthase activity (7fold for AqCbl and 20fold for MeCbl) as compared to the cofactor alone	703638	
2.1.1.13	methylcob(III)alamin	the addition of 0.05 mM methylcob(III)alamin to the crude extract results in an about 6fold increase in activity which is not greatly affected by the addition of cytochrome P450 reductase or reductase domain of neuronal nitric oxide synthase	703638	
2.1.1.13	Na+	at 67 mM 1.5 fold activity	441179	
2.1.1.13	NADPH	reactivation of methionine synthase is dependent on NADPH concentration in a hyperbolic manner with maximum activity at about 0.2 mM	703638	
2.1.1.13	NH4+	at 67 mM 1.5 fold activity	441179	
2.1.1.13	putrescine	up to 50% stimulation at 1 mm	441207	
2.1.1.13	S-adenosyl-L-methionine	required	659993	
2.1.1.13	S-adenosylmethionine	at about 0.0001 mM	441179	
2.1.1.13	spermidine	up to 2.5 fold stimulation at 1 mm	441207	
2.1.1.13	spermine	up to 4 fold stimulation at 1 mm	441207	
2.1.1.13	TrisHCl	at 67 mM 1.2 fold activity	441179	
2.1.1.13	vitamin B12	2 to 14 fold stimulation after addition to media due to posttranscriptional regulation	441212