1.14.13.29 alpha-naphthoflavone 60% activiation at 25 mM 1.14.13.29 additional information chronic abuse aspartame leads to 1.5fold increased enzyme activity in cerebrum and 25-fold in cerebellum, pattern of induction of CYP immunoreactive proteins, specific induction in the brain, not in hepatocytes, overview 1.14.13.29 additional information only inducer of nphA1 expression is 4-nitrophenol, no induction of nphA1 gene expression (in the presence of regulator NphR) by phenol, 2-nitrophenol, 3-nitrophenol, 2-hydroxyphenylacetate, 3-hydroxyphenylacetate, 4-hydroxyphenylacetate, 4-nitrocatechol 1.14.13.29 NphR positive regulatory protein for 4-nitrophenol hydroxylase