2.4.2.30	additional information	DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview	672969	
2.4.2.30	DNA	enzyme has an N-terminal binding domain	638000	
2.4.2.30	FAS	exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS	662089	
2.4.2.30	3-amino-1-methyl-5H-pyrido[4,3-b]indole	i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM	675627	
2.4.2.30	additional information	in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity	662087	
2.4.2.30	GDP	increases activity in absence of Mg2+	637994	
2.4.2.30	GTP	increases activity in absence of Mg2+	637994	
2.4.2.30	GTP(gammaS)	increases activity in absence of Mg2+	637994	
2.4.2.30	additional information	PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death	671255	
2.4.2.30	DNA	required	637998