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Gene ontology
Version 2014-12-22
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Details for vitamin-K-epoxide reductase (warfarin-sensitive) activity
1.1.4.1
Gene ontology ID
GO:0047057
Definition
Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
Synonyms
1. 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2. phylloquinone epoxide reductase activity
3. vitamin K1 epoxide reductase activity
References
1. EC 1.1.4.1
2. MetaCyc 1.1.4.1-RXN
3. Reactome: R-HSA-159790 "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)"
4. Reactome: R-HSA-6806647 "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)"
5. RHEA: 13817
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
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Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
oxidation-reduction process is a
oxidoreductase activity part of
oxidoreductase activity, acting on CH-OH group of donors is a
oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor is a
vitamin-K-epoxide reductase (warfarin-sensitive) activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
iodide oxidation is a
oxidative deethylation is a
oxidoreductase activity part of
1,1,1-trichloroethane reductive dehalogenase activity is a
1,1,2-trichloroethene reductive dehalogenase activity is a
1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity is a
1,1-dichloroethane reductive dehalogenase activity is a
1,2-dichloroethene reductive dehalogenase activity is a
2,4-dichloroaniline reductive dehalogenase activity is a
2,4-dichlorophenoxyacetate dehalogenase activity is a
2,5-dichlorohydroquinone reductive dehalogenase activity is a
2-chloro-N-isopropylacetanilide reductive dehalogenase activity is a
2-octaprenylphenol hydroxylase activity is a
2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity is a
3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity is a
3,3',5-tribromobisphenol A reductive dehalogenase activity is a
3,3'-dibromobisphenol A reductive dehalogenase activity is a
3,8-divinyl protochlorophyllide a 8-vinyl reductase activity is a
3-monobromobisphenol A reductive dehalogenase activity is a
alpha-ketoacid dehydrogenase activity is a
arsenate reductase activity is a
chlorate reductase activity is a
chromate reductase activity is a
crotonyl-CoA reductase activity is a
delta1-piperideine-6-carboxylate dehydrogenase activity is a
dihydronicotinamide riboside quinone reductase activity is a
dihydropterin oxidase activity is a
dimethylarsinate reductase activity is a
dioxygenase activity is a
epoxyqueuosine reductase activity is a
fatty acid alpha-hydroxylase activity is a
geranylgeranyl reductase activity is a
glycyl-radical enzyme activating activity is a
heme-copper terminal oxidase activity is a
hydroxymethylbutenyl pyrophosphate reductase activity is a
malolactic enzyme activity is a
monooxygenase activity is a
NADPH-adrenodoxin reductase activity is a
NADPH:sulfur oxidoreductase activity is a
ortho-trichlorophenol reductive dehalogenase activity is a
oxidoreductase activity, acting on a heme group of donors is a
oxidoreductase activity, acting on a sulfur group of donors is a
oxidoreductase activity, acting on CH or CH2 groups is a
oxidoreductase activity, acting on CH-OH group of donors is a
(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity is a
(R)-2-hydroxyglutarate dehydrogenase activity is a
(R)-mandelate dehydrogenase activity is a
(R)-pantolactone dehydrogenase (flavin) activity is a
(S)-mandelate dehydrogenase activity is a
1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity is a
1-phenylethanol dehydrogenase activity is a
2,4,4-trimethyl-1-pentanol dehydrogenase activity is a
2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity is a
2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity is a
2-hydroxyglutarate dehydrogenase activity is a
2-oxo-acid reductase activity is a
20-hydroxy-leukotriene B4 omega oxidase activity is a
3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity is a
3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity is a
3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity is a
3-hydroxycyclohexanone dehydrogenase activity is a
alcohol dehydrogenase (acceptor) activity is a
alkan-1-ol dehydrogenase (acceptor) activity is a
cellobiose dehydrogenase (acceptor) activity is a
chloral hydrate dehydrogenase activity is a
choline dehydrogenase activity is a
cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity is a
cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity is a
citronellol dehydrogenase activity is a
D-2-hydroxy-acid dehydrogenase activity is a
D-sorbitol dehydrogenase (acceptor) activity is a
dehydrogluconate dehydrogenase activity is a
endosulfan diol dehydrogenase activity is a
endosulfan hydroxyether dehydrogenase activity is a
fructose 5-dehydrogenase activity is a
glucose dehydrogenase activity is a
glucose-6-phosphate dehydrogenase (coenzyme F420) activity is a
glucose-fructose oxidoreductase activity is a
glucoside 3-dehydrogenase activity is a
glycerol dehydrogenase (acceptor) activity is a
glycolate dehydrogenase activity is a
hexitol dehydrogenase activity is a
hydroxyacid-oxoacid transhydrogenase activity is a
hydroxymethylmethylsilanediol oxidase activity is a
ketoreductase activity is a
lactate dehydrogenase activity is a
lactate-malate transhydrogenase activity is a
leukotriene B4 12-hydroxy dehydrogenase activity is a
limonene-1,2-diol dehydrogenase activity is a
malate dehydrogenase activity is a
myrtenol dehydrogenase activity is a
naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity is a
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor is a
oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor is a
vitamin-K-epoxide reductase (warfarin-insensitive) activity is a
vitamin-K-epoxide reductase (warfarin-sensitive) activity is a
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is a
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor is a
oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor is a
phenyllactate dehydrogenase activity is a
pinocarveol dehydrogenase activity is a
propan-2-ol:coenzyme F420 oxidoreductase activity is a
pyranose dehydrogenase (acceptor) activity is a
pyridoxine 5-dehydrogenase activity is a
sorbose dehydrogenase activity is a
uracil dehydrogenase activity is a
versicolorin reductase activity is a
oxidoreductase activity, acting on diphenols and related substances as donors is a
oxidoreductase activity, acting on halogen in donors is a
oxidoreductase activity, acting on hydrogen as donor is a
oxidoreductase activity, acting on iron-sulfur proteins as donors is a
oxidoreductase activity, acting on NAD(P)H is a
oxidoreductase activity, acting on other nitrogenous compounds as donors is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is a
oxidoreductase activity, acting on peroxide as acceptor is a
oxidoreductase activity, acting on phosphorus or arsenic in donors is a
oxidoreductase activity, acting on reduced flavodoxin as donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is a
oxidoreductase activity, acting on superoxide radicals as acceptor is a
oxidoreductase activity, acting on the aldehyde or oxo group of donors is a
oxidoreductase activity, acting on the CH-CH group of donors is a
oxidoreductase activity, acting on the CH-NH group of donors is a
oxidoreductase activity, acting on the CH-NH2 group of donors is a
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond is a
oxidoreductase activity, oxidizing metal ions is a
oxygen evolving activity is a
perchlorate reductase activity is a
phthalate dioxygenase reductase activity is a
pyrogallol hydroxytransferase activity is a
reduced coenzyme F420 dehydrogenase activity is a
reduced coenzyme F420 oxidase activity is a
reduced coenzyme F420:quinone oxidoreductase activity is a
selenate reductase activity is a
sphingosine hydroxylase activity is a
steroid dehydrogenase activity is a
sulfur oxygenase reductase activity is a
sulfur reductase activity is a
tetrachloroethene reductive dehalogenase activity is a
tetrahydrothiophene 1-oxide reductase activity is a
thyroxine 5'-deiodinase activity is a
thyroxine 5-deiodinase activity is a
trimethylarsine oxidase activity is a
tyramine-beta hydroxylase activity is a
uracil oxygenase activity is a
vinyl chloride reductive dehalogenase activity is a
violaxanthin de-epoxidase activity is a
thioredoxin reduction is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a