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Gene ontology
Version 2014-12-22
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Details for 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
1.14.13.95
Gene ontology ID
GO:0033778
Definition
Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+)
Synonyms
1. 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity
2. 7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity
3. CYP12
4. HCO 12alpha-hydroxylase activity
5. sterol 12alpha-hydroxylase activity
References
1. EC 1.14.13.95
2. RHEA: 10504
3. KEGG REACTION: R04826
4. MetaCyc 1.14.13.95-RXN
5. Reactome: R-HSA-192157 "CYP8B1 12-hydroxylates 4CHOL7aOLONE"
6. Reactome: R-HSA-193709 "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL"
7. Reactome: R-HSA-193845 "CYP8B1 12-hydroxylates 4CHOL7a,27DONE"
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