Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms
1. EC 4.2.1.742. MetaCyc LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN3. Reactome: R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA"
4. Reactome: R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA"
5. Reactome: R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA"
6. Reactome: R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA"
7. Reactome: R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA"