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Gene ontology
Version 2014-12-22
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Details for ATPase-coupled xenobiotic transmembrane transporter activity
7.6.2.2
Gene ontology ID
GO:0008559
Definition
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)
Synonyms
1. ATP phosphohydrolase (xenobiotic-exporting)
2. ATP-dependent xenobiotic transmembrane transporter activity
3. MDR protein
4. multidrug resistance exporter
5. multidrug-resistance protein
6. P-glycoprotein
7. PDR protein
8. pleiotropic-drug-resistance protein
9. xenobiotic ABC transporter
10. xenobiotic transmembrane transporting ATPase activity
References
1. EC 7.6.2.2
2. MetaCyc 3.6.3.44-RXN
3. Reactome: R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region"
4. Reactome: R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
5. Reactome: R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
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