Any feedback?
Please rate this page
(ontology.php)
(0/150)

BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
use AND (NOT) or OR
use AND (NOT) or OR
restrict to BRENDA links:
Details for oxidized purine nucleobase lesion DNA N-glycosylase activity
3.2.2.23
Gene ontology ID
GO:0008534
Definition
Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site
Comment
Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
Synonyms
1. 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity
2. 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity
3. 8-oxoguanine DNA glycosylase activity
4. bifunctional DNA glycosylase activity
5. deoxyribonucleate glycosidase activity
6. DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]
7. DNA glycosylase/AP-lyase activity
8. DNA glycosylase/beta-lyase activity
9. DNA-formamidopyrimidine glycosylase activity
10. Fapy-DNA glycosylase activity
11. formamidopyrimidine-DNA glycosylase activity
12. Fpg protein
13. oxidized purine base lesion DNA N-glycosylase activity
14. purine-specific oxidized base lesion DNA N-glycosylase activity
References
1. GOC: elh
2. PMID 11554296
3. EC 3.2.2.23
4. MetaCyc 3.2.2.23-RXN
5. Reactome: R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase"
6. Reactome: R-HSA-110243 "Cleavage of 8-oxoguanine by OGG1 glycosylase"
7. Reactome: R-HSA-110244 "Cleavage of formamidopyrimidine (FapyG) by OGG1 glycosylase"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology