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Gene ontology
Version 2014-12-22
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Details for ribonuclease III activity
3.1.26.3
Gene ontology ID
GO:0004525
Definition
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt
Synonyms
1. pre-mRNA 3'-end processing endonuclease
2. ribonuclease 3 activity
3. RNase III activity
References
1. PMID 11157775
2. PMID 15242644
3. EC 3.1.26.3
4. MetaCyc 3.1.26.3-RXN
5. Reactome: R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA"
6. Reactome: R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA"
7. Reactome: R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"
Legend
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is a part of the parent element
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derives from the parent element
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