3.1.26.3Gene ontology ID
GO:0004525
Definition
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt
Synonyms
1. pre-mRNA 3'-end processing endonuclease
2. ribonuclease 3 activity
3. RNase III activity
References
1. PMID 111577752. PMID 152426443. EC 3.1.26.34. MetaCyc 3.1.26.3-RXN5. Reactome: R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA"
6. Reactome: R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA"
7. Reactome: R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"
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derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA