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Gene ontology
Version 2014-12-22
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Details for hydroxymethylglutaryl-CoA synthase activity
2.3.3.10
Gene ontology ID
GO:0004421
Definition
Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
Comment
Note that this function was formerly EC:4.1.3.5.
Synonyms
1. (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
2. (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
3. 3-hydroxy-3-methylglutaryl CoA synthetase activity
4. 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
5. 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
6. 3-hydroxy-3-methylglutaryl-CoA synthase activity
7. 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
8. acetoacetyl coenzyme A transacetase activity
9. acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
10. beta-hydroxy-beta-methylglutaryl-CoA synthase activity
11. HMG-CoA synthase activity
12. hydroxymethylglutaryl coenzyme A synthase activity
13. hydroxymethylglutaryl coenzyme A-condensing enzyme
14. hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
References
1. EC 2.3.3.10
2. RHEA: 10188
3. KEGG REACTION: R01978
4. MetaCyc HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
5. Reactome: R-HSA-191323 "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA"
6. Reactome: R-HSA-73918 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
transferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer is a
hydroxymethylglutaryl-CoA synthase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
Atg8 ligase activity is a
CDP-alcohol phosphotransferase activity is a
glucanosyltransferase activity is a
Kdo transferase activity is a
mannosylphosphate transferase activity is a
molybdopterin molybdotransferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring acyl groups other than amino-acyl groups is a
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer is a
(R)-citramalate synthase activity is a
2-(2'-methylthio)ethylmalate synthase activity is a
2-(3'-methylthio)propylmalate synthase activity is a
2-(4'-methylthio)butylmalate synthase activity is a
2-(5'-methylthio)pentylmalate synthase activity is a
2-(6'-methylthio)hexylmalate synthase activity is a
2-(7'-methylthio)heptylmalate synthase activity is a
2-ethylmalate synthase activity is a
2-hydroxyglutarate synthase activity is a
2-isopropylmalate synthase activity is a
2-methylcitrate synthase activity is a
3-ethylmalate synthase activity is a
3-propylmalate synthase activity is a
ATP citrate synthase activity is a
citrate synthase activity is a
decylcitrate synthase activity is a
decylhomocitrate synthase activity is a
homocitrate synthase activity is a
hydroxymethylglutaryl-CoA synthase activity is a
malate synthase activity is a
sulfoacetaldehyde acetyltransferase activity is a
transferase activity, transferring aldehyde or ketonic groups is a
transferase activity, transferring alkyl or aryl (other than methyl) groups is a
transferase activity, transferring glycosyl groups is a
transferase activity, transferring nitrogenous groups is a
transferase activity, transferring one-carbon groups is a
transferase activity, transferring phosphorus-containing groups is a
transferase activity, transferring selenium-containing groups is a
transferase activity, transferring sulfur-containing groups is a
UDP-L-rhamnose synthase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a