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Gene ontology
Version 2014-12-22
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Details for peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
3.5.1.52
Gene ontology ID
GO:0000224
Definition
Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue
Synonyms
1. glycopeptidase activity
2. glycopeptide N-glycosidase activity
3. jack-bean glycopeptidase
4. N-glycanase activity
5. N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity
6. N-oligosaccharide glycopeptidase activity
7. peptide:N-glycanase
8. PNGase
9. PNGase A
10. PNGase F
References
1. EC 3.5.1.52
2. MetaCyc 3.5.1.52-RXN
3. Reactome: R-HSA-8850594 "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins"
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