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Gene ontology
Version 2014-12-22
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Details for IkappaB kinase activity
2.7.11.10
Gene ontology ID
GO:0008384
Definition
Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein
Comment
Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
Synonyms
1. ATP:IkappaB protein phosphotransferase activity
2. CHUK
3. ikappaB kinase activity
4. IKBKA
5. IKBKB
6. IKK
7. IKK-1
8. IKK-2
9. inhibitor of NF-kappaB kinase activity
10. inhibitor of NFkappaB kinase activity
11. STK12
12. TANK-binding kinase 1 activity
13. TBK1
References
1. EC 2.7.11.10
2. MetaCyc 2.7.11.10-RXN
3. Reactome: R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex"
4. Reactome: R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
positive regulation of biological process is a
positive regulation of DNA-binding transcription factor activity is a
positive regulation of NF-kappaB transcription factor activity is a
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation part of
IkappaB kinase activity part of
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
positive regulation of biological process is a
positive regulation by symbiont of entry into host is a
positive regulation of action potential is a
positive regulation of asexual reproduction is a
positive regulation of biomineralization is a
positive regulation of cellular process is a
positive regulation of circadian rhythm is a
positive regulation of developmental pigmentation is a
positive regulation of developmental process is a
positive regulation of DNA-binding transcription factor activity is a
positive regulation of CREB transcription factor activity is a
positive regulation of hh target transcription factor activity is a
positive regulation of NF-kappaB transcription factor activity is a
epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation part of
IkappaB kinase activity part of
regulation of I-kappaB phosphorylation
regulation of I-kappaB kinase/NF-kappaB signaling
NIK/NF-kappaB signaling
positive regulation of dosage compensation by inactivation of X chromosome is a
positive regulation of establishment of protein localization is a
positive regulation of establishment of RNA localization to telomere is a
positive regulation of growth is a
positive regulation of guanyl-nucleotide exchange factor activity is a
positive regulation of hemostasis is a
positive regulation of immune system process is a
positive regulation of lipid localization is a
positive regulation of locomotion is a
positive regulation of membrane depolarization is a
positive regulation of membrane hyperpolarization is a
positive regulation of metabolic process is a
positive regulation of mRNA alternative polyadenylation is a
positive regulation of multi-organism process is a
positive regulation of multicellular organismal process is a
positive regulation of nitrogen utilization is a
positive regulation of phosphorus utilization is a
positive regulation of posttranscriptional gene silencing is a
positive regulation of protein localization to cell-cell junction is a
positive regulation of protein localization to synapse is a
positive regulation of reproductive process is a
positive regulation of response to stimulus is a
positive regulation of short-term synaptic potentiation is a
positive regulation of signaling is a
positive regulation of sulfur utilization is a
positive regulation of telomerase RNA localization to Cajal body is a
positive regulation of transport is a
positive regulation of viral process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
regulation of carbon utilization is a
regulation of cellular process is a
cell redox homeostasis is a
modulation by symbiont of host cellular process is a
regulation of actin filament-based process is a
regulation of binding of sperm to zona pellucida is a
regulation of cartilage condensation is a
regulation of cell activation is a
regulation of cell adhesion molecule production is a
regulation of cell aging is a
regulation of cell communication is a
regulation of cell cycle is a
regulation of cell death is a
regulation of cell differentiation is a
regulation of cell division is a
regulation of cell killing is a
regulation of cell population proliferation is a
regulation of cell wall organization or biogenesis is a
regulation of cellular component biogenesis is a
regulation of cellular component movement is a
regulation of cellular component organization is a
regulation of cellular localization is a
regulation of cellular metabolic process is a
regulation of cellular pH reduction is a
regulation of cellular response to alcohol is a
regulation of cellular response to alkaline pH is a
regulation of cellular response to drug is a
regulation of cellular response to gamma radiation is a
regulation of cellular response to growth factor stimulus is a
regulation of cellular response to insulin stimulus is a
regulation of cellular response to macrophage colony-stimulating factor stimulus is a
regulation of cellular response to manganese ion is a
regulation of cellular response to oxidopamine is a
regulation of cellular response to stress is a
regulation of cellular response to testosterone stimulus is a
regulation of cellular response to thapsigargin is a
regulation of cellular response to tunicamycin is a
regulation of cellular response to very-low-density lipoprotein particle stimulus is a
regulation of cellular response to X-ray is a
regulation of chromosome segregation is a
regulation of conjugation is a
regulation of cytolysis is a
regulation of establishment or maintenance of cell polarity is a
regulation of horizontal cell localization is a
regulation of membrane depolarization is a
regulation of microtubule-based process is a
regulation of myelination is a
regulation of peroxidase activity is a
regulation of phenotypic switching is a
regulation of protein folding is a
regulation of response to cell cycle checkpoint signaling is a
regulation of secretion by cell is a
regulation of single-species biofilm formation is a
regulation of stomatal movement is a
regulation of transmembrane transport is a
regulation of transposition is a
regulation of vacuolar transport is a
regulation of vesicle-mediated transport is a
signal transduction is a
apoptotic signaling pathway is a
bile acid signaling pathway is a
calmodulin dependent kinase signaling pathway is a
carbohydrate mediated signaling is a
cell surface receptor signaling pathway is a
chloroplast-nucleus signaling pathway is a
dopamine receptor signaling pathway is a
endoplasmic reticulum unfolded protein response is a
ER-nucleus signaling pathway is a
extracellular ATP signaling is a
G protein-coupled receptor signaling pathway is a
hormone-mediated signaling pathway is a
hydrogen peroxide mediated signaling pathway is a
hypoxia-inducible factor-1alpha signaling pathway is a
immune response-regulating signaling pathway is a
intracellular receptor signaling pathway is a
intracellular signal transduction is a
endosomal signal transduction is a
hippo signaling is a
inositol lipid-mediated signaling is a
MAPK cascade is a
ERK1 and ERK2 cascade is a
ERK5 cascade is a
MAP kinase activity part of
MAPK cascade involved in ascospore formation is a
MAPK cascade involved in axon regeneration is a
MAPK cascade involved in innate immune response is a
stress-activated MAPK cascade is a
phosphorelay signal transduction system is a
PKR signal transduction is a
protein kinase A signaling is a
protein kinase B signaling is a
protein kinase C signaling is a
protein kinase D signaling is a
RAM/MOR signaling pathway is a
second-messenger-mediated signaling is a
signal transduction by p53 class mediator is a
signal transduction in response to DNA damage is a
small GTPase mediated signal transduction is a
stress-activated protein kinase signaling cascade is a
TOR signaling is a
TRAF-mediated signal transduction is a
ligand-gated ion channel signaling pathway is a
lipoprotein particle mediated signaling is a
mitochondria-nucleus signaling pathway is a
necroptotic signaling pathway is a
neuronal signal transduction is a
osmosensory signaling pathway is a
pattern recognition receptor signaling pathway is a
peptidoglycan recognition protein signaling pathway is a
phototransduction is a
postsynaptic signal transduction is a
presynaptic signal transduction is a
receptor ligand activity part of
red or far-red light signaling pathway is a
regulation of blood pressure by chemoreceptor signaling pathway is a
regulation of floral organ abscission by signal transduction is a
salicylic acid mediated signaling pathway is a
serotonin receptor signaling pathway is a
signal transduction by conformational transition is a
signal transduction by protein phosphorylation is a
signal transduction in absence of ligand is a
signal transduction involved in cellular response to ammonium ion is a
signal transduction involved in filamentous growth is a
signal transduction involved in regulation of gene expression is a
sphingolipid mediated signaling pathway is a
regulation of circadian rhythm is a
regulation of developmental pigmentation is a
regulation of developmental process is a
regulation of estrogen receptor binding is a
regulation of growth is a
regulation of guanyl-nucleotide exchange factor activity is a
regulation of hemostasis is a
regulation of immune system process is a
regulation of interspecies interactions between organisms is a
regulation of localization is a
regulation of locomotion is a
regulation of membrane hyperpolarization is a
regulation of metabolic process is a
regulation of multi-organism process is a
regulation of multicellular organismal process is a
regulation of nitrogen utilization is a
regulation of phosphorus utilization is a
regulation of plasma lipoprotein particle levels is a
regulation of reproductive process is a
regulation of response to stimulus is a
regulation of signaling is a
regulation of sulfur utilization is a
regulation of biological quality is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a