Ontology explorer

GO:0004674

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate

1. protein kinase (phosphorylating) activity
2. protein phosphokinase activity
3. protein serine kinase activity
4. protein serine-threonine kinase activity
5. protein-serine kinase activity
6. serine kinase activity
7. serine protein kinase activity
8. serine(threonine) protein kinase activity
9. serine-specific protein kinase activity
10. serine/threonine protein kinase activity
11. threonine-specific protein kinase activity

1. GOC: bf
2. RHEA: 17989
3. RHEA: 46608
4. Reactome: R-HSA-109702 "PDPK1 phosphorylates AKT2"
5. Reactome: R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1"
6. Reactome: R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2"
7. Reactome: R-HSA-109860 "MAP2K1 phosphorylates MAPK3"
8. Reactome: R-HSA-109862 "MAP2K2 phosphorylates MAPK1"
9. Reactome: R-HSA-111919 "PKA phosphorylates CREB1"
10. Reactome: R-HSA-111970 "PKC phosphorylates GRK2"
11. Reactome: R-HSA-112342 "Inactivation of MAP2K1 by CDK1"
12. Reactome: R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex"
13. Reactome: R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1"
14. Reactome: R-HSA-1168638 "Activated IKK phosphorylates I-kappaB"
15. Reactome: R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta"
16. Reactome: R-HSA-1181149 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin"
17. Reactome: R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL"
18. Reactome: R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor"
19. Reactome: R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL"
20. Reactome: R-HSA-1358791 "Phosphorylation of USP8 by P-AKT"
21. Reactome: R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A"
22. Reactome: R-HSA-139908 "Phosphorylation of DLC2 by MAPK8"
23. Reactome: R-HSA-139918 "Phosphorylation of BIM by JNK"
24. Reactome: R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)"
25. Reactome: R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A"
26. Reactome: R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1"
27. Reactome: R-HSA-1458463 "p-AKT2 phosphorylates RGC2"
28. Reactome: R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor"
29. Reactome: R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation"
30. Reactome: R-HSA-156678 "Activation of Cdc25C"
31. Reactome: R-HSA-156682 "Regulation of NUDC by phosphorylation"
32. Reactome: R-HSA-156699 "Inactivation of Wee1 kinase"
33. Reactome: R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation"
34. Reactome: R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A"
35. Reactome: R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B"
36. Reactome: R-HSA-162657 "Inactivation of Myt1 kinase"
37. Reactome: R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1"
38. Reactome: R-HSA-1632857 "ULK1 phosphorylates AMBRA1:Beclin-1 complex"
39. Reactome: R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP"
40. Reactome: R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP"
41. Reactome: R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres"
42. Reactome: R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer"
43. Reactome: R-HSA-165162 "Phosphorylation of TSC2 by PKB"
44. Reactome: R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB"
45. Reactome: R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1"
46. Reactome: R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)"
47. Reactome: R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1"
48. Reactome: R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1"
49. Reactome: R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1"
50. Reactome: R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1"
51. Reactome: R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal"
52. Reactome: R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex"
53. Reactome: R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP"
54. Reactome: R-HSA-166286 "Multiple IRAK1 autophosphorylation steps"
55. Reactome: R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex"
56. Reactome: R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD"
57. Reactome: R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2"
58. Reactome: R-HSA-168140 "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex"
59. Reactome: R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes"
60. Reactome: R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes"
61. Reactome: R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes"
62. Reactome: R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2"
63. Reactome: R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain"
64. Reactome: R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor"
65. Reactome: R-HSA-174119 "Free APC/C phosphorylated by Plk1"
66. Reactome: R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1"
67. Reactome: R-HSA-176116 "Recruitment and activation of Chk1"
68. Reactome: R-HSA-176298 "Activation of claspin"
69. Reactome: R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3"
70. Reactome: R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2"
71. Reactome: R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2"
72. Reactome: R-HSA-193647 "IRAK is activated"
73. Reactome: R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate"
74. Reactome: R-HSA-195275 "Phosphorylation of APC component of the destruction complex"
75. Reactome: R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3"
76. Reactome: R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3"
77. Reactome: R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3"
78. Reactome: R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha"
79. Reactome: R-HSA-198270 "PDPK1 phosphorylates AKT at T308"
80. Reactome: R-HSA-198347 "AKT phosphorylates BAD"
81. Reactome: R-HSA-198371 "AKT phosphorylates GSK3"
82. Reactome: R-HSA-198599 "AKT phosphorylates MDM2"
83. Reactome: R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it"
84. Reactome: R-HSA-198611 "AKT phosphorylates IKKalpha"
85. Reactome: R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1"
86. Reactome: R-HSA-198621 "AKT phosphorylates caspase-9"
87. Reactome: R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473"
88. Reactome: R-HSA-198669 "p38MAPK phosphorylates MSK1"
89. Reactome: R-HSA-198731 "ERK1/2 activates ELK1"
90. Reactome: R-HSA-198746 "ERK1/2/5 activate RSK1/2/3"
91. Reactome: R-HSA-198756 "ERK1/2 phosphorylates MSK1"
92. Reactome: R-HSA-199298 "AKT phosphorylates CREB1"
93. Reactome: R-HSA-199299 "AKT phosphorylates FOXO transcription factors"
94. Reactome: R-HSA-199839 "AKT can phosphorylate RSK"
95. Reactome: R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)"
96. Reactome: R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133"
97. Reactome: R-HSA-199910 "MSK1 activates ATF1"
98. Reactome: R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133"
99. Reactome: R-HSA-199929 "ERK5 activates the transcription factor MEF2"
100. Reactome: R-HSA-199935 "MSK1 activates CREB"
101. Reactome: R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)"
102. Reactome: R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation"
103. Reactome: R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta"
104. Reactome: R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI"
105. Reactome: R-HSA-201717 "CSNK2-mediated phosphorylation of DVL"
106. Reactome: R-HSA-202222 "Phosphorylation of PKC theta"
107. Reactome: R-HSA-202437 "Phosphorylation of CARMA1"
108. Reactome: R-HSA-202459 "Phosphorylation of Bcl10"
109. Reactome: R-HSA-202500 "Activation of IKK complex"
110. Reactome: R-HSA-202510 "Activation of TAK1-TAB2 complex"
111. Reactome: R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB"
112. Reactome: R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4"
113. Reactome: R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)"
114. Reactome: R-HSA-2028583 "Phosphorylation of YAP by LATS2"
115. Reactome: R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)"
116. Reactome: R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3"
117. Reactome: R-HSA-2028598 "Phosphorylation of YAP by LATS1"
118. Reactome: R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)"
119. Reactome: R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)"
120. Reactome: R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2"
121. Reactome: R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N"
122. Reactome: R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N"
123. Reactome: R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N"
124. Reactome: R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N"
125. Reactome: R-HSA-2029454 "Autophosphorylation of PAK1"
126. Reactome: R-HSA-2029460 "PAK1 phosphorylates LIMK1"
127. Reactome: R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI"
128. Reactome: R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1"
129. Reactome: R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase"
130. Reactome: R-HSA-211164 "AKT phosphorylates FOXO1A"
131. Reactome: R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197"
132. Reactome: R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop"
133. Reactome: R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19"
134. Reactome: R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9"
135. Reactome: R-HSA-2214351 "PLK1 phosphorylates GORASP1"
136. Reactome: R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex"
137. Reactome: R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant"
138. Reactome: R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex"
139. Reactome: R-HSA-2396007 "IRF3 is phosphorylated by TBK1"
140. Reactome: R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD"
141. Reactome: R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3"
142. Reactome: R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1"
143. Reactome: R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)"
144. Reactome: R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2"
145. Reactome: R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it"
146. Reactome: R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9"
147. Reactome: R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)"
148. Reactome: R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors"
149. Reactome: R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1"
150. Reactome: R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK"
151. Reactome: R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)"
152. Reactome: R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2"
153. Reactome: R-HSA-2430535 "MASTL phosphorylates ENSA"
154. Reactome: R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms"
155. Reactome: R-HSA-2470508 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin"
156. Reactome: R-HSA-2529020 "CK2 phosphorylates condensin I subunits"
157. Reactome: R-HSA-2562526 "PLK1 phosphorylates OPTN"
158. Reactome: R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation"
159. Reactome: R-HSA-2730856 "Autophosphorylation of PAK"
160. Reactome: R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1"
161. Reactome: R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1"
162. Reactome: R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1"
163. Reactome: R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6"
164. Reactome: R-HSA-2984226 "PLK1 phosphorylates NEK9"
165. Reactome: R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7"
166. Reactome: R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98"
167. Reactome: R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1"
168. Reactome: R-HSA-3000310 "AURKA phosphorylates PLK1"
169. Reactome: R-HSA-3000327 "PLK1 phosphorylates BORA"
170. Reactome: R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2"
171. Reactome: R-HSA-3209160 "Activated ERKs phosphorylate ERF"
172. Reactome: R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1"
173. Reactome: R-HSA-3222020 "NUAK1 phosphorylates TP53"
174. Reactome: R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6"
175. Reactome: R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1"
176. Reactome: R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)"
177. Reactome: R-HSA-3239014 "MAPKAPK5 phosphorylates TP53"
178. Reactome: R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5"
179. Reactome: R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407"
180. Reactome: R-HSA-3371435 "Constitutive phosphorylation by GSK3"
181. Reactome: R-HSA-3371531 "Constitutive phosphorylation by pERK1/2"
182. Reactome: R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART"
183. Reactome: R-HSA-349426 "Phosphorylation of MDM4 by CHEK2"
184. Reactome: R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM"
185. Reactome: R-HSA-349455 "Phosphorylation of MDM4 by ATM"
186. Reactome: R-HSA-374696 "Phosphorylation of L1 by p90rsk"
187. Reactome: R-HSA-3769394 "AKT phosphorylates CBY1"
188. Reactome: R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)"
189. Reactome: R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL"
190. Reactome: R-HSA-380272 "Plk1-mediated phosphorylation of Nlp"
191. Reactome: R-HSA-381091 "IRE1 dimer autophosphorylates"
192. Reactome: R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK"
193. Reactome: R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321"
194. Reactome: R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB"
195. Reactome: R-HSA-3858480 "WNT-dependent phosphorylation of DVL"
196. Reactome: R-HSA-389756 "AKT interacts and phosphorylates Cot"
197. Reactome: R-HSA-392752 "Phosphorylation of L1 by CK-II"
198. Reactome: R-HSA-3928577 "ROCK phosphorylates LIMK1,2"
199. Reactome: R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it"
200. Reactome: R-HSA-3928616 "Activated ROCK phosphorylates MRLCs"
201. Reactome: R-HSA-3928620 "PAK1 autophosphorylates"
202. Reactome: R-HSA-3928625 "PAKs autophosphorylate"
203. Reactome: R-HSA-3928640 "PAKs phosphorylate MLC"
204. Reactome: R-HSA-399939 "Autophosphorylation of PAK"
205. Reactome: R-HSA-399944 "Phosphorylation of CRMPs by Cdk5"
206. Reactome: R-HSA-399950 "Phosphorylation of cofilin by LIMK-1"
207. Reactome: R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta"
208. Reactome: R-HSA-399952 "Phosphorylation of LIMK-1 by PAK"
209. Reactome: R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS"
210. Reactome: R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins"
211. Reactome: R-HSA-4088134 "PLK1 phosphorylates FOXM1"
212. Reactome: R-HSA-419083 "Myosin phosphatase inactivation by ROCK"
213. Reactome: R-HSA-419087 "LIM kinase phosphorylation by ROCK"
214. Reactome: R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK"
215. Reactome: R-HSA-419644 "Transphosphorylation of pLIMK1"
216. Reactome: R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha"
217. Reactome: R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2"
218. Reactome: R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP"
219. Reactome: R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding"
220. Reactome: R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation"
221. Reactome: R-HSA-4332363 "Autophosphorylation and activation of CAMK2"
222. Reactome: R-HSA-4332388 "Activation of MAP3K7 in response to WNT"
223. Reactome: R-HSA-4411383 "NLK phosphorylates TCF/LEF"
224. Reactome: R-HSA-4411402 "Activation of NLK"
225. Reactome: R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)"
226. Reactome: R-HSA-442739 "PDPK1 phosphorylates RSKs"
227. Reactome: R-HSA-442832 "PAK phosphorylates cortactin"
228. Reactome: R-HSA-445072 "Interaction of PAK1 with Rac1-GTP"
229. Reactome: R-HSA-446694 "IRAK4 phosphorylates IRAK1"
230. Reactome: R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates"
231. Reactome: R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK"
232. Reactome: R-HSA-448955 "Phosphorylation of MEF2 proteins by p38"
233. Reactome: R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3"
234. Reactome: R-HSA-450325 "c-FOS activation by phospho ERK1/2"
235. Reactome: R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)"
236. Reactome: R-HSA-450474 "MK2 phosphorylates BRF1"
237. Reactome: R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1"
238. Reactome: R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP"
239. Reactome: R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2."
240. Reactome: R-HSA-451152 "MAP kinase p38 phosphorylates KSRP"
241. Reactome: R-HSA-451347 "Activation of JNK by DSCAM"
242. Reactome: R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A"
243. Reactome: R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD"
244. Reactome: R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1"
245. Reactome: R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation"
246. Reactome: R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation"
247. Reactome: R-HSA-5213464 "RIPK1 is phosphorylated"
248. Reactome: R-HSA-5213466 "RIPK3 is phosphorylated"
249. Reactome: R-HSA-5218814 "PAK2 autophorylates"
250. Reactome: R-HSA-5218821 "PDK1 phosphorylates PKC"
251. Reactome: R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732"
252. Reactome: R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21"
253. Reactome: R-HSA-5218906 "RIPK3 phosphorylates MLKL"
254. Reactome: R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27"
255. Reactome: R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB"
256. Reactome: R-HSA-5229343 "AXIN is phosphorylated in the destruction complex"
257. Reactome: R-HSA-5260201 "p-AKT2 phosphorylates C2CD5"
258. Reactome: R-HSA-5357472 "PAK1-3 autophosphorylates"
259. Reactome: R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin"
260. Reactome: R-HSA-5357831 "CYLD is phosphorylated by IKK"
261. Reactome: R-HSA-5578777 "DMPK phosphorylates PLN"
262. Reactome: R-HSA-5607722 "Active NIK phosphorylates IKKA dimer"
263. Reactome: R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB"
264. Reactome: R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates"
265. Reactome: R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta"
266. Reactome: R-HSA-5610718 "CK1 phosphorylates p-GLI2"
267. Reactome: R-HSA-5610722 "CK1 phosphorylates p-GLI3"
268. Reactome: R-HSA-5610730 "GSK3 phosphorylates p-GLI2"
269. Reactome: R-HSA-5610732 "GSK3 phosphorylates p-GLI3"
270. Reactome: R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit"
271. Reactome: R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338"
272. Reactome: R-HSA-5627775 "Autophosphorylation of PAK1,2,3"
273. Reactome: R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer"
274. Reactome: R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer"
275. Reactome: R-HSA-5635841 "GLI proteins are phosphorylated"
276. Reactome: R-HSA-5635842 "ULK3 phosphorylates GLI"
277. Reactome: R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)"
278. Reactome: R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores"
279. Reactome: R-HSA-5668545 "NIK autophosphorylates on T559"
280. Reactome: R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)"
281. Reactome: R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase"
282. Reactome: R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK"
283. Reactome: R-HSA-5669250 "PAK1 phosphorylates FLNA"
284. Reactome: R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A"
285. Reactome: R-HSA-5671919 "Activated CIT phosphorylates MRLCs"
286. Reactome: R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated"
287. Reactome: R-HSA-5672010 "Active mTORC1 phosphorylates ULK1"
288. Reactome: R-HSA-5672828 "mTORC1 phosphorylates AKT1S1"
289. Reactome: R-HSA-5672948 "MARK3 phosphorylates KSR1"
290. Reactome: R-HSA-5672973 "MAP2Ks phosphorylate MAPKs"
291. Reactome: R-HSA-5672978 "RAF phosphorylates MAP2K dimer"
292. Reactome: R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1"
293. Reactome: R-HSA-5675194 "Activated MAPK phosphorylates RAF1"
294. Reactome: R-HSA-5675198 "Activated MAPKs phosphorylate BRAF"
295. Reactome: R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1"
296. Reactome: R-HSA-5679205 "ULK1 phosphorylates Beclin-1"
297. Reactome: R-HSA-5682026 "MRN bound to shortened telomeres activates ATM"
298. Reactome: R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer"
299. Reactome: R-HSA-5682598 "ATM phosphorylates HERC2"
300. Reactome: R-HSA-5682983 "ATM phosphorylates WHSC1"
301. Reactome: R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs"
302. Reactome: R-HSA-5683792 "p-T68-CHEK2 autophosphorylates"
303. Reactome: R-HSA-5683801 "CHEK2 phosphorylates BRCA1"
304. Reactome: R-HSA-5683964 "ATM phosphorylates EYA1-4"
305. Reactome: R-HSA-5684096 "CDK2 phosphorylates RBBP8"
306. Reactome: R-HSA-5684140 "ATM phosphorylates RBBP8"
307. Reactome: R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs"
308. Reactome: R-HSA-5685156 "ATR phosphorylates RPA2"
309. Reactome: R-HSA-5685230 "CHEK1 phosphorylates RAD51"
310. Reactome: R-HSA-5685242 "CHEK1 phosphorylates BRCA2"
311. Reactome: R-HSA-5686578 "Activated ATM phosphorylates ABL1"
312. Reactome: R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C"
313. Reactome: R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4"
314. Reactome: R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3"
315. Reactome: R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5"
316. Reactome: R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3"
317. Reactome: R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1"
318. Reactome: R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs"
319. Reactome: R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1"
320. Reactome: R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN"
321. Reactome: R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs"
322. Reactome: R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1"
323. Reactome: R-HSA-5693536 "ATM phosphorylates MDC1"
324. Reactome: R-HSA-5693540 "MRN activates ATM"
325. Reactome: R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs"
326. Reactome: R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM"
327. Reactome: R-HSA-5693575 "DNA-PKcs autophosphorylates"
328. Reactome: R-HSA-5693598 "ATM phosphorylates NBN"
329. Reactome: R-HSA-5693609 "ATM phosphorylates TP53 at S15"
330. Reactome: R-HSA-5694441 "CSNK1D phosphorylates SEC23"
331. Reactome: R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA"
332. Reactome: R-HSA-6795290 "TORC2 complex phosphorylates SGK1"
333. Reactome: R-HSA-6795460 "SGK1 phosphorylates MDM2"
334. Reactome: R-HSA-6795473 "PDPK1 phosphorylates SGK1"
335. Reactome: R-HSA-6798372 "ATM phosphorylates DYRK2"
336. Reactome: R-HSA-6798374 "DYRK2 phosphorylates TP53"
337. Reactome: R-HSA-6799097 "ATM phosphorylates ZNF420"
338. Reactome: R-HSA-6799246 "CHEK1 phosphorylates TP53"
339. Reactome: R-HSA-6799332 "ATR phosphorylates TP53"
340. Reactome: R-HSA-6799409 "HIPK2 phosphorylates TP53"
341. Reactome: R-HSA-6800490 "ATM phosphorylates PIDD1"
342. Reactome: R-HSA-6801666 "PLK2 phosphorylates CENPJ"
343. Reactome: R-HSA-6801675 "PLK2 phosphorylates NPM1"
344. Reactome: R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks"
345. Reactome: R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks"
346. Reactome: R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks"
347. Reactome: R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks"
348. Reactome: R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers"
349. Reactome: R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks"
350. Reactome: R-HSA-6802973 "PLK3 phosphorylates CDC25C"
351. Reactome: R-HSA-6804266 "CHEK2 phosphorylates TTC5"
352. Reactome: R-HSA-6804276 "ATM phosphorylates TTC5"
353. Reactome: R-HSA-6804955 "ATM phosphorylates MDM2"
354. Reactome: R-HSA-6805059 "CK2:FACT phosphorylates TP53"
355. Reactome: R-HSA-6805103 "AURKA phosphorylates TP53"
356. Reactome: R-HSA-6805126 "AURKB phosphorylates TP53"
357. Reactome: R-HSA-6805276 "CDK5 phosphorylates TP53"
358. Reactome: R-HSA-6805285 "PLK3 phosphorylates TP53"
359. Reactome: R-HSA-6805399 "TAF1 phosphorylates TP53"
360. Reactome: R-HSA-6805479 "TP53RK phosphorylates TP53"
361. Reactome: R-HSA-6805640 "AKT phosphorylates KAT6A"
362. Reactome: R-HSA-6805785 "AKT phosphorylates PHF20"
363. Reactome: R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter"
364. Reactome: R-HSA-6811454 "MAPKs phosphorylate PP2A"
365. Reactome: R-HSA-6814409 "CK2 phosphorylates PDCL"
366. Reactome: R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine"
367. Reactome: R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1"
368. Reactome: R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2"
369. Reactome: R-HSA-69685 "CHEK2 phosphorylates TP53"
370. Reactome: R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM"
371. Reactome: R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1"
372. Reactome: R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1"
373. Reactome: R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2"
374. Reactome: R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta"
375. Reactome: R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD"
376. Reactome: R-HSA-8850945 "Casein kinase II phosphorylates PTEN"
377. Reactome: R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends"
378. Reactome: R-HSA-8852317 "PLK1 phosphorylates GTSE1"
379. Reactome: R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation"
380. Reactome: R-HSA-8853444 "AURKA phosphorylates PHLDA1"
381. Reactome: R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer"
382. Reactome: R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156"
383. Reactome: R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B"
384. Reactome: R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C"
385. Reactome: R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A"
386. Reactome: R-HSA-8863895 "IKKB phosphorylates SNAP23"
387. Reactome: R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2"
388. Reactome: R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1"
389. Reactome: R-HSA-8868344 "CDK5:p25 phosphorylates lamin A"
390. Reactome: R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1"
391. Reactome: R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2"
392. Reactome: R-HSA-8868666 "CDK5:p25 phosphorylates JUN"
393. Reactome: R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3"
394. Reactome: R-HSA-8873929 "Casein kinase II phosphorylates STARD10"
395. Reactome: R-HSA-8876446 "p-ULK1 phosphorylates DENND3"
396. Reactome: R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B"
397. Reactome: R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300"
398. Reactome: R-HSA-8878054 "HIPK2 phosphorylates RUNX1"
399. Reactome: R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling"
400. Reactome: R-HSA-8939963 "Activated AKT phosphorylates RUNX2"
401. Reactome: R-HSA-8940100 "CDK1 phosphorylates VCPIP1"
402. Reactome: R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6"
403. Reactome: R-HSA-8944454 "mTORC1 phosphorylates MAF1"
404. Reactome: R-HSA-8948039 "FUNDC1 is phosphorylated by CK2"
405. Reactome: R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17"
406. Reactome: R-HSA-8948757 "AKT phosphorylates MKRN1"
407. Reactome: R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates"
408. Reactome: R-HSA-9007539 "CHEK1 phosphorylates E2F6"
409. Reactome: R-HSA-9008480 "GSK3B phosphorylates RUNX2"
410. Reactome: R-HSA-9008822 "PPM1D dephosphorylates RUNX2"
411. Reactome: R-HSA-9009208 "Activated ERKs phosphorylate RUNX2"
412. Reactome: R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD"
413. Reactome: R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex"
414. Reactome: R-HSA-9022314 "HIPK2 phosphorylates MECP2"
415. Reactome: R-HSA-9023132 "AURKB phosphorylates MECP2 at S423"
416. Reactome: R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3"
417. Reactome: R-HSA-9032863 "CDK5 phosphorylates NTRK2"
418. Reactome: R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions"
419. Reactome: R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2"
420. Reactome: R-HSA-918229 "Phosphorylation and release of IRF3/IRF7"
421. Reactome: R-HSA-933525 "Phosphorylation and release of IRF7"
422. Reactome: R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1"
423. Reactome: R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex"
424. Reactome: R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP"
425. Reactome: R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex"
426. Reactome: R-HSA-9604328 "AKT1 phosphorylates NOTCH4"
427. Reactome: R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates"
428. Reactome: R-HSA-9619515 "AMPK phosphorylates MAPT"
429. Reactome: R-HSA-9619843 "ERKs phosphorylate RSKs"
430. Reactome: R-HSA-9620004 "RSKs autophosphorylate"
431. Reactome: R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR"
432. Reactome: R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345"
433. Reactome: R-HSA-9627089 "CASP9 is phosphorylated at T125"
434. Reactome: R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen"
435. Reactome: R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2"
436. Reactome: R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9"
437. Reactome: R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9"
438. Reactome: R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9"
439. Reactome: R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9"
440. Reactome: R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9"
441. Reactome: R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR"
442. Reactome: R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex"
443. Reactome: R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88"
444. Reactome: R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex"
445. Reactome: R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR"

is an element of the parent element

is a part of the parent element

is related to the parent element

derives from the parent element

// at least 1 tissue/ enzyme/ localization link in this branch

// tissue/ enzyme/ localization link to BRENDA