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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for transcription coactivator activity
Gene ontology ID
GO:0003713
Definition
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator
Synonyms
1. RNA polymerase II transcription co-activator activity
2. RNA polymerase II transcription coactivator activity
3. RNA polymerase II transcription mediator activity
4. transcription co-activator activity
5. transcription coactivator activity
References
1. GOC: txnOH-2018
2. PMID 10213677
3. PMID 16858867
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