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Gene ontology
Version 2014-12-22
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Details for MAP kinase activity
2.7.11.24
Gene ontology ID
GO:0004707
Definition
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli
Synonyms
1. ATP:protein phosphotransferase (MAPKK-activated) activity
2. ERK
3. ERK1
4. ERK2
5. extracellular signal-regulated kinase activity
6. MAP kinase 1 activity
7. MAP kinase 2 activity
8. MAPK
9. MBP kinase I activity
10. MBP kinase II activity
11. mitogen activated kinase activity
12. mitogen-activated protein kinase activity
13. myelin basic protein kinase activity
14. SAP kinase activity
15. SAPK
16. stress-activated kinase activity
17. stress-activated protein kinase activity
References
1. GOC: ma
2. ISBN 0198547684
3. EC 2.7.11.24
4. KEGG REACTION: R00162
5. MetaCyc 2.7.11.24-RXN
6. Reactome: R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2"
7. Reactome: R-HSA-198733 "ERK5 is activated"
8. Reactome: R-HSA-445079 "Phosphorylation of L1 by ERK"
9. Reactome: R-HSA-451366 "Activation of p38MAPK by DSCAM"
10. Reactome: R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2."
11. Reactome: R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2"
12. Reactome: R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2."
13. Reactome: R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2."
14. Reactome: R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter"
15. Reactome: R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345"
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Gene ontology