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Literature summary extracted from

  • Seely, J.E.; Marshall, F.D.
    Inhibition of carnosine synthetase by spermidine (1982), Pept. Antibiot. Biosynth. Funct. (Kleinkauf H. et al. eds. ), , 347-352.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.11 1,10-Diaminodecane 10 mM, 43% loss of activity Rattus norvegicus
6.3.2.11 1,8-diaminooctane 10 mM, 27% loss of activity Rattus norvegicus
6.3.2.11 5-Aminopentanoate noncompetitive with respect to beta-Ala Rattus norvegicus
6.3.2.11 5-Aminopentanol 10 mM, 11% loss of activity Rattus norvegicus
6.3.2.11 6-Aminohexanol 10 mM, 10% loss of activity Rattus norvegicus
6.3.2.11 Aminoethanol 10 mM, 17% loss of activity Rattus norvegicus
6.3.2.11 n-butylamine 10 mM, 15% loss of activity Rattus norvegicus
6.3.2.11 n-Hexylamine 10 mM, 34% loss of activity Rattus norvegicus
6.3.2.11 n-octylamine 10 mM, 58% loss of activity Rattus norvegicus
6.3.2.11 spermidine
-
Bos taurus
6.3.2.11 spermidine
-
Gallus gallus
6.3.2.11 spermidine mixed type with respect to beta-alanine Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.11 Bos taurus
-
-
-
6.3.2.11 Gallus gallus
-
-
-
6.3.2.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.11 brain
-
Gallus gallus
-
6.3.2.11 brain
-
Rattus norvegicus
-
6.3.2.11 heart
-
Gallus gallus
-
6.3.2.11 heart
-
Rattus norvegicus
-
6.3.2.11 heart
-
Bos taurus
-
6.3.2.11 muscle
-
Gallus gallus
-
6.3.2.11 muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.11 ATP + L-His + 4-aminobutanoate
-
Gallus gallus AMP + phosphate + homocarnosine
-
?
6.3.2.11 ATP + L-His + 4-aminobutanoate
-
Rattus norvegicus AMP + phosphate + homocarnosine
-
?
6.3.2.11 ATP + L-His + 4-aminobutanoate
-
Bos taurus AMP + phosphate + homocarnosine
-
?
6.3.2.11 ATP + L-His + beta-Ala
-
Gallus gallus ADP + phosphate + carnosine
-
?
6.3.2.11 ATP + L-His + beta-Ala
-
Rattus norvegicus ADP + phosphate + carnosine
-
?
6.3.2.11 ATP + L-His + beta-Ala
-
Bos taurus ADP + phosphate + carnosine
-
?