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Literature summary extracted from

  • Linnett, P.E.; Tipper, D.J.
    Cell wall polymers of Bacillus sphaericus: activities of enzymes involved in peptidoglycan precursor synthesis during sporulation (1974), J. Bacteriol., 120, 342-354.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.9 L-Glu 50 mM, product inhibition Lysinibacillus sphaericus
6.3.2.9 Mg2+
-
 Lysinibacillus sphaericus
6.3.2.9 Mn2+ weak Lysinibacillus sphaericus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.4 ATP + Ala + Ala Lysinibacillus sphaericus enzyme involved in peptidoglycan precursor synthesis during sporulation ?
-
 ?
6.3.2.4 ATP + Ala + Ala Lysinibacillus sphaericus 9602 enzyme involved in peptidoglycan precursor synthesis during sporulation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Lysinibacillus sphaericus
-
 9602
-
6.3.2.4 Lysinibacillus sphaericus 9602
-
 9602
-
6.3.2.7 Lysinibacillus sphaericus
-
-
-
6.3.2.8 Lysinibacillus sphaericus
-
 9602
-
6.3.2.8 Lysinibacillus sphaericus 9602
-
 9602
-
6.3.2.9 Lysinibacillus sphaericus
-
 9602
-
6.3.2.9 Lysinibacillus sphaericus 9602
-
 9602
-
6.3.2.10 Lysinibacillus sphaericus
-
 9602
-
6.3.2.10 Lysinibacillus sphaericus 9602
-
 9602
-
6.3.2.13 Lysinibacillus sphaericus
-
 9602
-
6.3.2.13 Lysinibacillus sphaericus 9602
-
 9602
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.4 sporulating cell the activity decays at the end of the vegetative growth and increases again later in the sporulating process Lysinibacillus sphaericus
-
6.3.2.4 vegetative the activity decays at the end of the vegetative growth and increases again later in the sporulating process Lysinibacillus sphaericus
-
6.3.2.7 vegetative the activity of L-lysine ligase, which is required only for the synthesis of vegetative peptidoglycan, decays after the end of of vegetative growth, except for a small but reproducible increase in activity just prior to the onset of refractility Lysinibacillus sphaericus
-
6.3.2.8 sporulating cell 50% decay of activity after the end of exponential cell division Lysinibacillus sphaericus
-
6.3.2.9 vegetative specific activity decays by 50% after the end of exponential cell division Lysinibacillus sphaericus
-
6.3.2.10 sporulating cell
-
 Lysinibacillus sphaericus
-
6.3.2.10 vegetative
-
 Lysinibacillus sphaericus
-
6.3.2.13 sporulating cell the enzyme is absent from cells harvested before 4 h of sporulation Lysinibacillus sphaericus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + Ala + Ala enzyme involved in peptidoglycan precursor synthesis during sporulation Lysinibacillus sphaericus ?
-
 ?
6.3.2.4 ATP + Ala + Ala enzyme involved in peptidoglycan precursor synthesis during sporulation Lysinibacillus sphaericus 9602 ?
-
 ?
6.3.2.7 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys
-
 Lysinibacillus sphaericus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys
-
 ?
6.3.2.7 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys
-
 Lysinibacillus sphaericus 9602 ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala
-
 Lysinibacillus sphaericus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala
-
 Lysinibacillus sphaericus 9602 ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
 ?
6.3.2.9 ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
 Lysinibacillus sphaericus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
 ?
6.3.2.10 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala
-
 Lysinibacillus sphaericus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
 ?
6.3.2.10 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala
-
 Lysinibacillus sphaericus 9602 ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
 ?
6.3.2.13 ATP + UDP-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
-
 Lysinibacillus sphaericus ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
-
 ?
6.3.2.13 ATP + UDP-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
-
 Lysinibacillus sphaericus 9602 ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
-
 ?