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Literature summary extracted from

  • Wheeler, M.H.; Greenblatt, G.A.
    The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease (1988), Exp. Mycol., 12, 151-160.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.1.1.252 agriculture the effect of melanin inhibitors on the enzyme activity can be used to predict their effect in preventing rice blast disease Pyricularia oryzae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.252 2,3,4,5,6-Pentachlorobenzyl alcohol
-
 Pyricularia oryzae
1.1.1.252 Chlobenthiazone
-
 Pyricularia oryzae
1.1.1.252 Fthalide
-
 Pyricularia oryzae
1.1.1.252 additional information the effect of melanin inhibitors on the enzyme activity can be used to predict their effect in preventing rice blast disease Pyricularia oryzae
1.1.1.252 N-Methyl-2-quinolone weak Pyricularia oryzae
1.1.1.252 Pyroquilon
-
 Pyricularia oryzae
1.1.1.252 s-Triazolo[4,3-a]-quinoline weak Pyricularia oryzae
1.1.1.252 Tricyclazole
-
 Pyricularia oryzae
4.2.1.94 1,2,5,6-Tetrahydro-4H-pyrrolo[3,2,1-i,j]quinolin-4-one i.e. pyroquilon Pyricularia oryzae
4.2.1.94 2,3,4,5,6-Pentachlorobenzyl alcohol
-
 Pyricularia oryzae
4.2.1.94 4,5,6,7-Tetrachorophthalide i.e. fthalide Pyricularia oryzae
4.2.1.94 4,5-Dihydro-4-methyltetrazolo-[1,5-a]-quinazolin-5-one
-
 Pyricularia oryzae
4.2.1.94 4-Chloro-3-methylbenzothiazol-2[3H]-one i.e. chlorobenthiazone Pyricularia oryzae
4.2.1.94 5-Methyl-1,2,4-triazolo[3,4-b]-benzothiazole i.e. tricyclazole Pyricularia oryzae
4.2.1.94 coumarin
-
 Pyricularia oryzae
4.2.1.94 N-Methyl-2-quinolone
-
 Pyricularia oryzae
4.2.1.94 s-Triazolo[4,3-a]-quinoline
-
 Pyricularia oryzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.252 1,3,6,8-Tetrahydroxynaphthalene + NADPH Pyricularia oryzae the enzyme is involved in the pentaketide pathway of melanin and flaviolin and 2-HJ Scytalone + NADP+
-
 ?
4.2.1.94 scytalone Pyricularia oryzae
-
 1,3,8-trihydroxynaphthalene + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.252 Pyricularia oryzae
-
-
-
4.2.1.94 Pyricularia oryzae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.94 appressorium
-
 Pyricularia oryzae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.252 1,3,6,8-Tetrahydroxynaphthalene + NADPH
-
 Pyricularia oryzae Scytalone + NADP+
-
 ?
1.1.1.252 1,3,6,8-Tetrahydroxynaphthalene + NADPH the enzyme is involved in the pentaketide pathway of melanin and flaviolin and 2-HJ Pyricularia oryzae Scytalone + NADP+
-
 ?
1.1.1.252 1,3,8-trihydroxynaphthalene + NADPH + H+
-
 Pyricularia oryzae vermelone + NADP+
-
 ?
4.2.1.94 scytalone
-
 Pyricularia oryzae 1,3,8-trihydroxynaphthalene + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.252 NADPH
-
 Pyricularia oryzae