Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Davie, E.W.; Fujikawa, K.; Kurachi, K.; Kisiel, W.
    The role of serine proteases in the blood coagulation cascade (1979), Adv. Enzymol. Relat. Areas Mol. Biol., 48, 277-318.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 antithrombin III inhibition is accelerated 300fold to 500fold by the addition of heparin, heparin alone has no effect Bos taurus
3.4.21.38 C1 esterase inhibitor
-
 Bos taurus
3.4.21.38 diisopropyl phosphofluoridate
-
 Bos taurus
3.4.21.38 Lima bean trypsin inhibitor
-
 Bos taurus
3.4.21.38 phenyl methylsulfonyl fluoride
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.38 additional information
-
 amino acid sequence of the heavy chain, the active site region contains Asp-Ala-Cys-Gln-Gly-Asp-Ser-Gly-Gly sequence Bos taurus
3.4.21.38 28000
-
 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds Bos taurus
3.4.21.38 46000
-
 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 factor VII + H2O Bos taurus enzyme is involved in the blood coagulation cascade ?
-
 ?
3.4.21.38 factor XI + H2O Bos taurus enzyme is involved in the blood coagulation cascade ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.38 proteolytic modification the conversion of factor XII to factor XIIa is due to the cleavage of a specific internal Arg-Val peptide bond Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 benzoyl arginine ethyl ester + H2O
-
 Bos taurus benzoyl-Arg + ethanol
-
 ?
3.4.21.38 factor VII + H2O enzyme is involved in the blood coagulation cascade Bos taurus ?
-
 ?
3.4.21.38 factor VII + H2O
-
 Bos taurus factor VIIa
-
 ?
3.4.21.38 factor XI + H2O
-
 Bos taurus factor XIa + ?
-
 ?
3.4.21.38 factor XI + H2O enzyme is involved in the blood coagulation cascade Bos taurus ?
-
 ?
3.4.21.38 N-benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O
-
 Bos taurus ?
-
 ?
3.4.21.38 plasminogen proactivator + H2O
-
 Bos taurus ?
-
 ?
3.4.21.38 prekallikrein + H2O
-
 Bos taurus ?
-
 ?
3.4.21.38 tosyl arginine methyl ester + H2O
-
 Bos taurus tosyl-Arg + methanol
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.38 dimer 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds Bos taurus