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Literature summary extracted from

  • Colman, R.W.; Bagdasarian, A.
    Human kallikrein and prekallikrein (1976), Methods Enzymol., 45, 303-322.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.4.21.34 IgG stabilizes Homo sapiens
3.4.21.34 stable to freezing and thawing Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.34 alpha2-Macroglobulin
-
Homo sapiens
3.4.21.34 antithrombin III
-
Homo sapiens
3.4.21.34 C1 esterase inhibitor
-
Homo sapiens
3.4.21.34 diisopropylfluorophosphate
-
Homo sapiens
3.4.21.34 diphenylcarbamoylfluoride
-
Homo sapiens
3.4.21.34 p-Carboethoxyphenyl epsilon-guanidine caproate
-
Homo sapiens
3.4.21.34 Soybean trypsin inhibitor
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.34 0.00156
-
Nalpha-toluenesulfonyl-L-arginine methyl ester
-
Bos taurus
3.4.21.34 0.0136
-
Nalpha-benzoyl-L-arginine ethyl ester
-
Homo sapiens
3.4.21.34 0.0962
-
Nalpha-benzoyl-L-arginine ethyl ester
-
Bos taurus
3.4.21.34 0.136
-
Nalpha-toluenesulfonyl-L-arginine methyl ester
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 cytosol
-
Homo sapiens 5829
-
3.4.21.34 cytosol
-
Bos taurus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.34 95000
-
gel filtration Homo sapiens
3.4.21.34 95000
-
gel filtration Bos taurus
3.4.21.34 99800
-
sedimentation equilibrium, kallikrein I Homo sapiens
3.4.21.34 163000
-
sedimentation equilibrium, kallikrein II Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 kininogen + H2O Homo sapiens cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation ?
-
?
3.4.21.34 kininogen + H2O Bos taurus cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Bos taurus
-
-
-
3.4.21.34 Homo sapiens
-
kallikrein I, kallikrein II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.34
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 plasma
-
Homo sapiens
-
3.4.21.34 plasma
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.34 additional information
-
-
Homo sapiens
3.4.21.34 additional information
-
-
Bos taurus

Storage Stability

EC Number Storage Stability Organism
3.4.21.34 -50°C, stable for several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 kininogen + H2O cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation Homo sapiens ?
-
?
3.4.21.34 kininogen + H2O cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation Bos taurus ?
-
?
3.4.21.34 Nalpha-Benzoyl-L-Arg ethyl ester + H2O
-
Homo sapiens Nalpha-Benzoyl-L-Arg + ethanol
-
?
3.4.21.34 Nalpha-Benzoyl-L-Arg ethyl ester + H2O
-
Bos taurus Nalpha-Benzoyl-L-Arg + ethanol
-
?
3.4.21.34 Nalpha-toluenesulfonyl-L-arginine methyl ester + H2O
-
Homo sapiens Nalpha-toluenesulfonyl-L-arginine + methanol
-
?
3.4.21.34 Nalpha-toluenesulfonyl-L-arginine methyl ester + H2O
-
Bos taurus Nalpha-toluenesulfonyl-L-arginine + methanol
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.34 7.65
-
-
Homo sapiens
3.4.21.34 8.8
-
-
Bos taurus