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Literature summary extracted from

  • Thompson, A.R.
    Structure, function and molecular defects of factor IX (1986), Blood, 67, 565-572.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.22 factor VIII in modified form, established in the activation of factor X Homo sapiens
3.4.21.22 Phospholipid increases the activation of factor X Homo sapiens
3.4.21.22 platelet factor 3 in vivo, established in the activation of factor X Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.22 antithrombin III a nonspecific protein inhibitor, in presence of heparin, this forms a stable or covalent-like intermediate with the factor IXa Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.22 Ca2+ factor IX activation is the first calcium-dependent reaction in intrinsic system clotting Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.22 factor X + H2O Homo sapiens a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.22 blood
-
 Homo sapiens
-
3.4.21.22 endothelium factor IXa binds specifically to the surface of endothelial cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.22 factor X + H2O a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa Homo sapiens ?
-
 ?
3.4.21.22 factor X + H2O
-
 Homo sapiens factor Xa activated form ?