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Literature summary extracted from

  • Cummins, P.M.; O'Connor, B.
    Bovine brain pyroglutamyl aminopeptidase (type-1): purification and characterisation of a neuropeptide-inactivating peptidase (1996), Int. J. Biochem. Cell Biol., 28, 883-893.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.19.3 dithiothreitol presence of disulfide-reducing agent such as dithiothreitol required Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.3 1,10-phenanthroline
-
Bos taurus
3.4.19.3 2-Iodoacetamide
-
Bos taurus
3.4.19.3 2-Pyrrolidone
-
Bos taurus
3.4.19.3 Cd2+
-
Bos taurus
3.4.19.3 Cu2+
-
Bos taurus
3.4.19.3 Hg2+
-
Bos taurus
3.4.19.3 NEM
-
Bos taurus
3.4.19.3 p-hydroxymercuribenzoate
-
Bos taurus
3.4.19.3 Zn2+
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.19.3 0.01364
-
pyroglutamyl-His-Pro-4-methylcoumarin 7-amide
-
Bos taurus
3.4.19.3 0.01536
-
pyroglutamyl-4-methylcoumarin 7-amide
-
Bos taurus
3.4.19.3 0.02076
-
Pyroglutamyl-beta-naphthylamide
-
Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.19.3 23700
-
gel filtration Bos taurus
3.4.19.3 24000
-
1 * 24000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.3 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.3
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.3 brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.19.3 additional information
-
-
Bos taurus

Storage Stability

EC Number Storage Stability Organism
3.4.19.3 -80°C, 17% loss of activity after 4 weeks Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.3 bombesin + H2O
-
Bos taurus pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
?
3.4.19.3 L-pyroglutamyl-His-Pro-4-methylcoumarin 7-amide + H2O
-
Bos taurus L-pyroglutamate + His-Pro-4-methylcoumarin 7-amide
-
?
3.4.19.3 luteinizing-hormone-releasing hormone + H2O
-
Bos taurus ?
-
?
3.4.19.3 neurotensin + H2O
-
Bos taurus pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
?
3.4.19.3 pyroglutamyl-4-methylcoumarin 7-amide + H2O
-
Bos taurus pyroglutamate + 7-amino-4-methylcoumarin
-
?
3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O
-
Bos taurus pyroglutamate + beta-naphthylamine
-
?
3.4.19.3 thyroliberin + H2O
-
Bos taurus pyroglutamate + His-Pro-NH2
-
?

Subunits

EC Number Subunits Comment Organism
3.4.19.3 monomer 1 * 24000, SDS-PAGE Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.19.3 8.5
-
-
Bos taurus