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Literature summary extracted from

  • Schoenberger, O.L.; Tschesche, H.
    N-Acetylalanine aminopeptidase. A new enzyme from human erythrocytes (1981), Hoppe-Seyler's Z. Physiol. Chem., 362, 865-873.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.4.19.1 loss of activity after freezing and lyophilization Homo sapiens
3.4.19.1 stabilized in a 0.1 M solution of ammonium sulfate Homo sapiens
3.4.19.1 unstable with organic solvents Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.1 di(2-pyridyl)disulfide
-
 Homo sapiens
3.4.19.1 PCMB
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.19.1 0.616
-
 N-acetyl-Ala-4-nitroanilide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.19.1 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.19.1 300000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.1
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.1 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.19.1 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.1 N-acetyl-Ala ethyl ester + H2O
-
 Homo sapiens N-acetyl-Ala + ethanol
-
 ?
3.4.19.1 N-acetyl-Ala p-nitroanilide + H2O
-
 Homo sapiens N-acetyl-Ala + p-nitroaniline
-
 ?
3.4.19.1 N-acetyl-Ala-Ala + H2O N-acetyl-Ala-Ala Homo sapiens N-acetyl-Ala + Ala
-
 ?
3.4.19.1 N-acetyl-Ala-Ala-Ala + H2O N-acetyl-Ala-Ala-Ala Homo sapiens N-acetyl-Ala + Ala-Ala
-
 ?
3.4.19.1 N-acetyl-Ala-Ala-Ala-Ala + H2O
-
 Homo sapiens N-acetyl-Ala + Ala-Ala-Ala
-
 ?
3.4.19.1 N-acetyl-Ala-Tyr-Ile + H2O
-
 Homo sapiens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.19.1 8.3
-
 hydrolysis of N-acetyl-Ala p-nitroanilide Homo sapiens
3.4.19.1 8.4
-
 hydrolysis of N-acetyl-Ala p-nitroanilide Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.19.1 7 9 about 55% of maximal activity at pH 7 and at pH 13 Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.19.1 5
-
 rapid loss of activity below Homo sapiens
3.4.19.1 5.4
-
 0.25 M ammonium sulfate, stable for 6 weeks Homo sapiens
3.4.19.1 6 8 stable Homo sapiens