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Literature summary extracted from

  • McDonald, J.K.; Reilly, T.J.; Zeitman, B.B.; Ellis, S.
    Dipeptidyl arylamidase II of the pituitary. Properties of lysylalanyl-beta-naphthylamide hydrolysis: inhibition by cations, distribution in tissues, and subcellular localization (1968), J. Biol. Chem., 243, 2028-2037.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.2 K+ inhibition by cations increases with the size of the ion Bos taurus
3.4.14.2 Li+ inhibition by cations increases with the size of the ion Bos taurus
3.4.14.2 Na+ inhibition by cations increases with the size of the ion Bos taurus
3.4.14.2 Na+
-
 Rattus norvegicus
3.4.14.2 puromycin 1 mM, 76% inhibition; inhibition by cations increases with the size of the ion Bos taurus
3.4.14.2 puromycin
-
 Rattus norvegicus
3.4.14.2 puromycin aminonucleoside inhibition by cations increases with the size of the ion Bos taurus
3.4.14.2 Tris 50 mM, 96% inhibition; inhibition by cations increases with the size of the ion Bos taurus
3.4.14.2 Tris
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.14.2 lysosome
-
 Rattus norvegicus 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.2 Bos taurus
-
-
-
3.4.14.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.2 adrenal gland
-
 Rattus norvegicus
-
3.4.14.2 brain
-
 Rattus norvegicus
-
3.4.14.2 hypophysis
-
 Rattus norvegicus
-
3.4.14.2 hypophysis
-
 Bos taurus
-
3.4.14.2 kidney
-
 Rattus norvegicus
-
3.4.14.2 liver
-
 Rattus norvegicus
-
3.4.14.2 pancreas
-
 Rattus norvegicus
-
3.4.14.2 spleen
-
 Rattus norvegicus
-
3.4.14.2 testis
-
 Rattus norvegicus
-
3.4.14.2 thymus
-
 Rattus norvegicus
-
3.4.14.2 thyroid gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.2 Ala-Ala-2-naphthylamide + H2O
-
 Rattus norvegicus Ala-Ala + 2-naphthylamine
-
 ?
3.4.14.2 Ala-Ala-2-naphthylamide + H2O
-
 Bos taurus Ala-Ala + 2-naphthylamine
-
 ?
3.4.14.2 Leu-Ala-2-naphthylamide + H2O
-
 Rattus norvegicus Leu-Ala + 2-naphthylamine
-
 ?
3.4.14.2 Leu-Ala-2-naphthylamide + H2O
-
 Bos taurus Leu-Ala + 2-naphthylamine
-
 ?
3.4.14.2 Lys-Ala-2-naphthylamide + H2O
-
 Rattus norvegicus Lys-Ala + 2-naphthylamine
-
 ?
3.4.14.2 Lys-Ala-2-naphthylamide + H2O
-
 Bos taurus Lys-Ala + 2-naphthylamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.2 5.5
-
-
 Rattus norvegicus
3.4.14.2 5.5
-
 hydrolysis of Lys-Ala-2-naphthylamide Bos taurus
3.4.14.2 7 7.5 hydrolysis of Ala-2-naphthylamide Bos taurus