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Literature summary extracted from
- Isolation and characterization of an aminopeptidase from Lactobacillus acidophilus (1984), Biochim. Biophys. Acta, 789, 26-36.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | D-leucine | - |
Lactobacillus acidophilus |  |
| 3.4.11.1 | L-alanine | - |
Lactobacillus acidophilus | |
| 3.4.11.1 | L-asparagine | - |
Lactobacillus acidophilus | |
| 3.4.11.1 | L-leucine | competitive | Lactobacillus acidophilus | |
| 3.4.11.1 | L-Leucyl ethyl ester | - |
Lactobacillus acidophilus | |
| 3.4.11.1 | L-lysine | - |
Lactobacillus acidophilus | |
| 3.4.11.1 | L-tyrosine | - |
Lactobacillus acidophilus | |
| 3.4.11.1 | L-valine | - |
Lactobacillus acidophilus | |
| 3.4.11.1 | p-chloromercuribenzoate | - |
Lactobacillus acidophilus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.1 | 7.2 | - |
L-Leu-Gly | similar value | Lactobacillus acidophilus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.1 | Br- | 4 mM, activation | Lactobacillus acidophilus | |
| 3.4.11.1 | Cl- | 4 mM, activation | Lactobacillus acidophilus | |
| 3.4.11.1 | Co2+ | activation | Lactobacillus acidophilus | |
| 3.4.11.1 | Mn2+ | activation | Lactobacillus acidophilus | |
| 3.4.11.1 | Ni2+ | activation | Lactobacillus acidophilus | |
| 3.4.11.1 | Zn2+ | contains 4 mol of tightly bound Zn2+ | Lactobacillus acidophilus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | 38400 | - |
4 * 38400, SDS-PAGE | Lactobacillus acidophilus |
| 3.4.11.1 | 156000 | - |
gel filtration | Lactobacillus acidophilus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | Proteins + H2O | Lactobacillus acidophilus | oxidized beta chain of insulin | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.1 | Lactobacillus acidophilus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.11.1 | - |
Lactobacillus acidophilus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | additional information | - |
- |
Lactobacillus acidophilus |
| 3.4.11.1 | 4.2 | - |
- |
Lactobacillus acidophilus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.1 | L-amino acid-peptide + H2O | fast hydrolysis of hydrophobic amino acids in N-terminal position | Lactobacillus acidophilus | amino acid + peptide | - |
? | |
| 3.4.11.1 | L-Leu-Gly + H2O | - |
Lactobacillus acidophilus | L-Leu + Gly | - |
? | |
| 3.4.11.1 | Proteins + H2O | oxidized beta chain of insulin | Lactobacillus acidophilus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.11.1 | tetramer | 4 * 38400, SDS-PAGE | Lactobacillus acidophilus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | 6 | 7 | - |
Lactobacillus acidophilus |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.1 | 4 | 9 | - |
Lactobacillus acidophilus |
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