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Literature summary extracted from
- Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains (1994), J. Biol. Chem., 269, 8780-8785.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.48 | spermidine | activation | Homo sapiens |  |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.3.48 | expression of PTP2C and DELTASH2-PTP2C in Escherichia coli | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.48 | H3VO4 | slight effect | Homo sapiens | |
| 3.1.3.48 | heparin | - |
Homo sapiens | |
| 3.1.3.48 | Zn2+ | - |
Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.48 | Ca2+ | 4-6fold increase of activity | Homo sapiens | |
| 3.1.3.48 | Mg2+ | 4-6fold increase of activity | Homo sapiens | |
| 3.1.3.48 | Mn2+ | 4-6fold increase of activity | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.48 | 68000 | - |
PTP2C, gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.48 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.48 | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.48 | 4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
| 3.1.3.48 | ENDpYINASL + H2O | - |
Homo sapiens | ENDYINASL + phosphate | - |
? | |
| 3.1.3.48 | lysozyme + H2O | reduced, carboxymethylated and maleylated | Homo sapiens | ? + phosphate | - |
? | |
| 3.1.3.48 | myelin basic protein + H2O | - |
Homo sapiens | ? + phosphate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.48 | 5 | 5.6 | substrates 4-nitrophenyl phosphate and ENDpYINASL, enzymes PTP2C and DELTASH2-PTP2C | Homo sapiens |
| 3.1.3.48 | 6.5 | 7.5 | substrates lysozyme and myelin basic protein, enzymes PTP2C and DELTASH2-PTP2C | Homo sapiens |
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Release 2023.1 (January 2023)
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