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Literature summary extracted from

  • Roome, J.; O'Hare, T.; Pilch, P.F.; Brautigan, D.L.
    Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors (1988), Biochem. J., 256, 493-500.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 H3VO4
-
 Homo sapiens
3.1.3.48 molybdate
-
 Homo sapiens
3.1.3.48 additional information unaffected by EDTA Homo sapiens
3.1.3.48 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.48 0.015
-
 phosphotyrosyl bovine serum albumin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.48 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 38000
-
 1 * 38000, SDS-PAGE Homo sapiens
3.1.3.48 40000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.48
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.48 6.6
-
 substrate bovine serum albumin, calculated as micromol phosphate released per min Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 bovine serum albumin + H2O
-
 Homo sapiens ? + phosphate
-
 ?
3.1.3.48 epidermal growth factor + H2O
-
 Homo sapiens ? + phosphate
-
 ?
3.1.3.48 insulin-like growth factor-1 + H2O
-
 Homo sapiens ? + phosphate
-
 ?
3.1.3.48 phosphotyrosine serum albumin + H2O
-
 Homo sapiens ? + phosphate
-
 ?
3.1.3.48 phosphotyrosyl bovine serum albumin + H2O
-
 Homo sapiens tyrosyl-bovine serum albumin + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.48 monomer 1 * 38000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 PTP-phosphatase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.48 7
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.48 5 9 pH 5: 13% of maximal activity, pH 9: 50% of maximum activity Homo sapiens