Literature summary extracted from

Sakakibara, R.; Uemura, M.; Hirata, T.; Okamura, N.; Kato, M.
Human placental fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase: its isozymic form, expression and characterization (1997), Biosci. Biotechnol. Biochem., 61, 1949-1952.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.3.46	expression in Escherichia coli	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.1.3.46	0.016	-	fructose 2,6-bisphosphate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.46	fructose 2,6-bisphosphate + H2O	Homo sapiens	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.105	Homo sapiens	-	-	-
3.1.3.46	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.7.1.105	recombinant enzyme	Homo sapiens

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
2.7.1.105	ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate	bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46	Homo sapiens	a
3.1.3.46	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate	bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase	Homo sapiens	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.105	placenta	-	Homo sapiens	-
3.1.3.46	placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.105	ATP + beta-D-fructose 6-phosphate	-	Homo sapiens	ADP + beta-D-fructose 2,6-bisphosphate	-	?
2.7.1.105	additional information	also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)	Homo sapiens	?	-	?
3.1.3.46	fructose 2,6-bisphosphate + H2O	-	Homo sapiens	fructose 6-phosphate + phosphate	-	?
3.1.3.46	fructose 2,6-bisphosphate + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)